Aerobic training and hydroalcoholic extracts of green tea improve pro-oxidant-antioxidant balance and histopathological score in the N-methyl-N-nitrosourea-induced prostate cancer model of rat

Authors

  • Zakaria Vahabzadeh Liver & Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Tel: 098 873 3664674, Fax: 098 873 3664674, E-mail: zakariav@yahoo.com
  • Mohammadraman Molodi Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Physiology and Pharmacology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Bahram Nikkho Department of Pathology and Clinical Laboratory Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Marziyeh Saghebjoo Department of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran
  • Saber Saedmocheshi Department of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran
  • Fatemeh Zamani Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Yazdan Roshani Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Sina Babanzadeh Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

DOI:

https://doi.org/10.17179/excli2019-1884

Keywords:

prostate cancer, pro-oxidant-antioxidant balance, prostate-specific antigen, Camellia sinensis, aerobic exercise

Abstract

Green tea is a main resource for catechins. Catechins as antioxidant compounds reduce the production of reactive oxygen species and they have a protective role in the development of cancer. As well as, aerobic exercise change free radicals with two contradictory mechanisms. Aerobic training promotes excessive production of free radicals resulting in oxidative stress. In contrast, it increases the total antioxidant capacity. In this study, effect of aerobic training and hydroalcoholic extract of green tea (HEGT) on the pro-oxidant-antioxidant balance (PAB), prostate-specific antigen (PSA) and histopathological score of cancerous tissue in the N-methyl-N-nitrosourea–induced prostate cancer was investigated. A rat model of prostate cancer was induced by hormonal change and N-Nitroso-N-methylurea (NMU). HEGT 0.1 % and 45 min of aerobic exercise in 5 days a week for eight weeks were scheduled. The presence of major catechins was approved using GC-MS. Histological study, PAB and PSA levels were used to monitor the preventive role of treatments. The prostate weights of cancerous rats were significantly higher than healthy controls (P<0.05). The PAB was only significantly higher in cancerous rats and cancerous rats receiving aerobic exercise (P<0.05). The mean of histological score of cancerous tissue was reduced in rat receiving HEGT and both HEGT and aerobic exercise. The amounts of PSA level did not significantly differ between the groups of this study (P>0.05). Our results provided laboratory and histological documentation for the preventive role of green tea extract in developing prostate cancer via its potential to re-establish the pro-oxidant-antioxidant balance.

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Published

2020-06-08

How to Cite

Vahabzadeh, Z., Molodi, M., Nikkho, B., Saghebjoo, M., Saedmocheshi, S., Zamani, F., … Babanzadeh, S. (2020). Aerobic training and hydroalcoholic extracts of green tea improve pro-oxidant-antioxidant balance and histopathological score in the N-methyl-N-nitrosourea-induced prostate cancer model of rat. EXCLI Journal, 19, 762–772. https://doi.org/10.17179/excli2019-1884

Issue

Vol. 19 (2020)

Section

Original articles

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