Meta-analysis of neuron specific enolase in predicting pediatric brain injury outcomes

Authors

  • Babak Nakhjavan-Shahraki Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mahmoud Yousefifard Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Alireza Oraii Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Arash Sarveazad Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
  • Mostafa Hosseini Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.17179/excli2017-405

Keywords:

biomarker, pediatric, traumatic brain injury

Abstract

A reliable biomarker has not been identified to predict the outcome of traumatic brain injury (TBI) in children. Therefore, the present systematic review and meta-analysis aimed to assess the association between neuron specific enolase (NSE) and traumatic brain injury (TBI) in children. Two independent reviewers searched electronic databases of EMBASE, Cochrane library, Medline and Scopus and then they summarized the results and did a quality control check. At the end, standardized mean difference (SMD) with 95 % confidence interval (CI) and performance of NSE were assessed. 10 studies were included in the present meta-analysis. Average serum (SMD=1.3; 95 % CI: 0.5 to 2.1; p=0.001) and CSF levels (SMD=2.45; 95 % CI: 1.04 to 3.8; p<0.0001) of NSE biomarker were significantly higher in children with TBI with unfavorable outcome compared with other children. Serum NSE had an area under the curve, sensitivity and specificity of 0.75 (95 % CI: 0.72 to 0.79), 0.74 (95 % CI: 0.64 to 0.82) and 0.69 (95 % CI: 0.59 to 0.77), respectively in prediction outcome of TBI. Positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of serum NSE were 2.4 (95 % CI: 1.7 to 3.3), 0.38 (95 % CI: 0.26 to 0.55) and 6.0 (95 % CI: 3.0 to 12.0), respectively. The results show that the performance of NSE is in a moderate level in prediction of unfavorable outcome in children with TBI. However, data in this aspect is not sufficient and more studies are needed.

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Published

2017-07-03

How to Cite

Nakhjavan-Shahraki, B., Yousefifard, M., Oraii, A., Sarveazad, A., & Hosseini, M. (2017). Meta-analysis of neuron specific enolase in predicting pediatric brain injury outcomes. EXCLI Journal, 16, 995–1008. https://doi.org/10.17179/excli2017-405

Issue

Vol. 16 (2017)

Section

Original articles

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