Unraveled roles of hyaluronan in severe COVID-19

Authors

  • Pawared Ontong Department of Community Medical Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand, Tel.: 662-441-4376, Fax: 662-441-4380; E-mail: pawared.ont@mahidol.ac.th https://orcid.org/0000-0002-4582-667X
  • Virapong Prachayasittikul Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand https://orcid.org/0000-0001-7942-1083

DOI:

https://doi.org/10.17179/excli2020-3215

Keywords:

COVID-19, SARS-CoV-2, acute respiratory distress syndrome, hyaluronan, cytokine storm, 4-methylumbelliferone, hyaluronidase

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic viral pneumonia caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). Most of the severe COVID-19 patients come up with trouble breathing, persistent pressure in the chest and developing to acute respiratory distress syndrome (ARDS) with a high mortality rate. Infected lung brings about uncontrolled inflammation followed by the fluid leakage and accumulation of extracellular matrix. Hyaluronan (HA) is an essential component of the extracellular matrix (ECM) and plays crucial roles in both biological and pathological states. It is also primarily located within the respiratory airways and is uprising during COVID-19 infection. Hitherto, the association between COVID-19 pathophysiology and HA is still unclear. Herein, we provide an overview of the pathophysiology of SARS-CoV-2 infection in conjunction with the involvement of HA and the diminution of HA for therapeutic potential of COVID-19. For severe patients, HA depletion may be beneficial for preventing ARDS while monitoring and managing HA level in lung may improve survival rate of patients.

Downloads

Published

2021-01-15

How to Cite

Ontong, P., & Prachayasittikul, V. (2021). Unraveled roles of hyaluronan in severe COVID-19. EXCLI Journal, 20, 117–125. https://doi.org/10.17179/excli2020-3215

Issue

Vol. 20 (2021)

Section

Review articles

License

Copyright (c) 2021 Pawared Ontong, Virapong Prachayasittikul

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).

Most read articles by the same author(s)

<< < 1 2 3 > >>