Molecular pathways in the development of HPV-induced cervical cancer

Authors

  • Farnaz Rasi Bonab Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran
  • Amir Baghbanzadeh Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Moslem Ghaseminia Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Nadia Bolandi Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Ahad Mokhtarzadeh Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Amini Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Kianoosh Dadashzadeh Department of Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran
  • Khalil Hajiasgharzadeh Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Behzad Baradaran Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Tel: +98 41 3337 1440, Fax: +98 41 3337 1311, Postcode: 5166614766, E-mail: baradaranb@tbzmed.ac.ir https://orcid.org/0000-0002-8642-6795
  • Hossein Bannazadeh Baghi Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98 41 3336 4661, E-mail: hbannazadeh@tbzmed.ac.ir https://orcid.org/0000-0002-2513-5361

DOI:

https://doi.org/10.17179/excli2021-3365

Keywords:

cervical cancer, HPV, oncoprotein, E6 and E7, signaling pathway

Abstract

Recently, human papillomavirus (HPV) has gained considerable attention in cervical cancer research studies. It is one of the most important sexually transmitted diseases that can affect 160 to 289 out of 10000 persons every year. Due to the infectious nature of this virus, HPV can be considered a serious threat. The knowledge of viral structure, especially for viral oncoproteins like E6, E7, and their role in causing cancer is very important. This virus has different paths (PI3K/Akt, Wnt/β-catenin, ERK/MAPK, and JAK/STA) that are involved in the transmission of signaling paths through active molecules like MEK (pMEK), ERK (pERK), and Akt (pAkt). It’s eventually through these paths that cancer is developed. Precise knowledge of these paths and their signals give us the prognosis to adopt appropriate goals for prevention and control of these series of cancer.

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Published

2021-02-12

How to Cite

Rasi Bonab, F., Baghbanzadeh, A., Ghaseminia, M., Bolandi, N., Mokhtarzadeh, A., Amini, M., … Bannazadeh Baghi, H. (2021). Molecular pathways in the development of HPV-induced cervical cancer. EXCLI Journal, 20, 320–337. https://doi.org/10.17179/excli2021-3365

Issue

Vol. 20 (2021)

Section

Review articles

License

Copyright (c) 2021 Farnaz Rasi Bonab, Amir Baghbanzadeh, Moslem Ghaseminia, Nadia Bolandi, Ahad Mokhtarzadeh, Mohammad Amini, Kianoosh Dadashzadeh, Khalil Hajiasgharzadeh, Behzad Baradaran, Hossein Bannazadeh Baghi

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