Molecular mechanisms linking stress and insulin resistance

Authors

  • Habib Yaribeygi Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran. E-mail: habib.yari@yahoo.com https://orcid.org/0000-0002-1706-6212
  • Mina Maleki Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0003-4723-3058
  • Alexandra E. Butler Research Department, Royal College of Surgeons in Ireland, Bahrain, PO Box 15503, Adliya, Bahrain https://orcid.org/0000-0002-5762-3917
  • Tannaz Jamialahmadi Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0001-9521-3153
  • Amirhossein Sahebkar Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: amir_saheb2000@yahoo.com https://orcid.org/0000-0002-8656-1444

DOI:

https://doi.org/10.17179/excli2021-4382

Keywords:

Diabetes mellitus, insulin resistance, stress, immune system, insulin signal transduction

Abstract

To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.

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Published

2022-01-24

How to Cite

Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2022). Molecular mechanisms linking stress and insulin resistance. EXCLI Journal, 21, 317–334. https://doi.org/10.17179/excli2021-4382

Issue

Vol. 21 (2022)

Section

Review articles

Categories

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Copyright (c) 2022 Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar

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