The effects of low-toxic herbicide Roundup and glyphosate on mitochondria

Authors

  • Olha M. Strilbytska Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0003-3277-2294
  • Sviatoslav A. Tsiumpala Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0001-8842-9853
  • Ivanna I. Kozachyshyn Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0002-2456-6389
  • Tetiana Strutynska Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0003-2854-1303
  • Nadia Burdyliuk Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0001-9590-3672
  • Volodymyr Lushchak Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine. E-mail: volodymyr.lushchak@pnu.edu.ua https://orcid.org/0000-0001-5602-3330
  • Oleh Lushchak Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine. E-mail: oleh.lushchak@pnu.edu.ua https://orcid.org/0000-0002-4627-1987

DOI:

https://doi.org/10.17179/excli2021-4478

Keywords:

Roundup, glyphosate, mitochondria, oxidative stress

Abstract

The effects of pesticides on the health of non-target living organisms in agricultural areas are critically important aspects for their safe use. Their release into the environment is an inevitable aspect for predicting and evaluation of the risk of their application. Roundup, a glyphosate-based herbicide, has been designed as an effective pesticide against weeds and now is the most widely used agrochemicals around the world due to its highly specific action of the biosynthesis of certain amino acids in plants. Despite it is claimed to be low toxic for not-target organisms, due to its broad application Roundup and products of its degradation were detected in organisms of diverse animals and humans. In this review, we describe animal and human studies of general adverse effects of Roundup and its principal substance glyphosate with focus on endocrine disruption, oxidative stress and behavioral disorders. At mechanistic level, we focus on the potential toxicity of the herbicide Roundup and glyphosate as effectors of bioenergetic functions of mitochondria. Their effects on mitochondrial membrane potential and oxidative phosphorylation are among described to date critical components responsible for its toxicity. Finally, we discuss general molecular mechanisms potentially involved in the interaction between glyphosate and mitochondria which to some extent are associated with generation of reactive oxygen species.

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Published

2022-01-10

How to Cite

Strilbytska, O. M., Tsiumpala, S. A., Kozachyshyn, I. I., Strutynska, T., Burdyliuk, N., Lushchak, V., & Lushchak, O. (2022). The effects of low-toxic herbicide Roundup and glyphosate on mitochondria. EXCLI Journal, 21, 183–196. https://doi.org/10.17179/excli2021-4478

Issue

Vol. 21 (2022)

Section

Review articles

Categories

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Copyright (c) 2022 Olha M. Strilbytska, Sviatoslav A. Tsiumpala, Ivanna I. Kozachyshyn, Tetiana Strutynska, Nadia Burdyliuk, Volodymyr Lushchak, Oleh Lushchak

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