Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction

Authors

  • Alavala Matta Reddy Department of Zoology, School of Life and Health Sciences, Adikavi Nannaya University, Rajahmundry 533296, Andhra Pradesh, India https://orcid.org/0000-0002-6955-2650
  • Mumtaz Iqbal College of Arts and Science, University of South Florida, Tampa, FL33620, USA https://orcid.org/0000-0002-7541-2259
  • Hitesh Chopra Chitkara College of Pharmacy, Chitkara University, Punjab140401, India https://orcid.org/0000-0001-8867-7603
  • Shaheda Urmi Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL33612, USA https://orcid.org/0000-0003-0954-9879
  • Sunil Junapudi Department of Pharmaceutical Chemistry, Geethanjali College of Pharmacy, Cherryal, Keesara, Medchalmalkajgiri District, Telangana, 501301, India https://orcid.org/0000-0002-9216-6096
  • Shabana Bibi Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan; Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, China. E-mail: dazzling.grin@gmail.com https://orcid.org/0000-0001-9585-9042
  • Santosh Kumar Gupta National Institute of Plant Genome Research, New Delhi 110067, India https://orcid.org/0000-0003-2245-8488
  • Viajaya Nirmala Pangi School of Life and Health Sciences, Adikavi Nannaya University, Rajahamahendravaram, Andhra Pradesh, India. E-mail: vijaya.nirmala3@gmail.com https://orcid.org/0000-0002-3059-7667
  • Inderbir Singh Chitkara College of Pharmacy, Chitkara University, Punjab140401, India https://orcid.org/0000-0002-1860-4246
  • Mohamed M. Abdel-Daim Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231 Jeddah 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt https://orcid.org/0000-0002-4341-2713

DOI:

https://doi.org/10.17179/excli2022-4935

Keywords:

vitamin D, mitochondrial dysfunction, oxidative stress, cell damage, inflammation, cardiac diseases

Abstract

Vitamin D, a secosteroid hormone, appears to have significant beneficial effects on various physiological systems, including the musculoskeletal system. Vitamin D assists in the regulation of numerous critical biological functions and physiological processes in humans, including inflammation, oxidative stress, and mitochondrial respiration, and is also linked to cardiac diseases. It is also reported that vitamin D plays a central role in molecular and cellular mechanisms, which reduce oxidative stress, and tissue damage and regulate cellular health. On the other side, hypovitaminosis D reduces mitochondrial activity and increases oxidative stress and inflammation in the body. Hypervitaminosis D increases the prevalence and severity of cellular damage. It has also been reported that vitamin D is involved in many functions of the reproductive system in human and critically play an important role in the reproductive tissues of women and men. Its role is very well defined, starting from female menarche to menopause, pregnancy, and lactation, and finally in male fertility. Hence, the appropriate amount of vitamin D is necessary to maintain the normal function of cell organelles. Based on recent studies, it is understood that vitamin D is involved in the biological activities of mitochondria in cells, especially in cardiomyocytes. In this review, we emphasized the role of vitamin D in mitochondrial respiration, which could significantly influence heart health and human reproduction.

Author Biography

Shabana Bibi, Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan; Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, China. E-mail: dazzling.grin@gmail.com

shabana_bibi@ynu.edu.cn (läuft nicht mehr)

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Published

2022-07-20

How to Cite

Matta Reddy, A., Iqbal, M., Chopra, H., Urmi, S., Junapudi, S., Bibi, S., … Abdel-Daim, M. M. (2022). Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction. EXCLI Journal, 21, 967–990. https://doi.org/10.17179/excli2022-4935

Issue

Vol. 21 (2022)

Section

Review articles

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Copyright (c) 2022 Alavala Matta Reddy, Mumtaz Iqbal, Hitesh Chopra, Shaheda Urmi, Sunil Junapudi, Shabana Bibi, Santosh Kumar Gupta, Viajaya Nirmala Pangi, Inderbir Singh, Mohamed M. Abdel-Daim

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