Association between 15 insertion/deletion genetic polymorphisms and risk of schizophrenia using pooled samples

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DOI:

https://doi.org/10.17179/excli2022-5734

Keywords:

insertion/deletion polymorphisms, schizophrenia, pooled samples

Abstract

Schizophrenia is a psychiatric syndrome that affects approximately 1 % of the world population and is among the top 10 reasons for disability. In this case-control study, we investigated the association between 15 insertion/deletion (Indel) polymorphisms and schizophrenia risk using pooled samples. In the present case-control study, 361 individuals with schizophrenia and 360 healthy individuals were included in the study. We examined the insertion/deletion polymorphisms in APOB, ADRA2B, PDCD6IP, LRPAP1, TLR2, DHFR, VEGF, HLA-G, TPA, DBH, UCP2, FADS2, MDM2, TP53 and SLC6A4 genes. Our results revealed that the Del allele of the HLA-G 14bp Indel polymorphism increased the risk of schizophrenia (OR=1.23, 95 % CI=1.01-1.52, p=0.045) and the Alu- allele of the TPA Alu+/Alu- polymorphism negatively associated with the schizophrenia risk (OR=0.67, 95 % CI=0.54-0.82, p<0.001).

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Published

2023-02-28

How to Cite

Bordbar, M., & Saadat, M. (2023). Association between 15 insertion/deletion genetic polymorphisms and risk of schizophrenia using pooled samples. EXCLI Journal, 22, 310–314. https://doi.org/10.17179/excli2022-5734

Issue

Vol. 22 (2023)

Section

Original articles

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Copyright (c) 2023 Maedeh Bordbar, Mostafa Saadat

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