Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease

Authors

  • Syed Mohd. Danish Rizvi Department of Biosciences, Integral University, Lucknow, India
  • Sibhghatulla Shaikh Department of Biosciences, Integral University, Lucknow, India
  • Shah Mohammad Abbas Waseem Department of Physiology, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, India
  • Shazi Shakil Center of Innovation in Personalized Medicine, Faculty of Applied Medical Sciences,King Abdulaziz University, Jeddah, Saudi Arabia
  • Adel M. Abuzenadah Center of Innovation in Personalized Medicine, Faculty of Applied Medical Sciences,King Abdulaziz University, Jeddah, Saudi Arabia
  • Deboshree Biswas Department of Biosciences, Integral University, Lucknow, India
  • Shams Tabrez King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
  • Ghulam Md. Ashraf King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
  • Mohammad Amjad Kamal King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Enzymoic, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

DOI:

https://doi.org/10.17179/excli2015-252

Keywords:

Alzheimer's disease, anti-diabetic drugs, amyloid beta, beta-secretase, sodium glucose, co-transporters, Type 2 Diabetes Mellitus

Abstract

Recent data have suggested a strong possible link between Type 2 Diabetes Mellitus and Alzheimer's disease (AD), although exact mechanisms linking the two are still a matter of research and debate. Interestingly, both are diseases with high incidence and prevalence in later years of life. The link appears so strong that some scientists use Alzheimer's and Type 3 Diabetes interchangeably. In depth study of recent data suggests that the anti diabetic drugs not only have possible role in treatment of Alzheimer's but may also arrest the declining cognitive functions associated with it. The present review gives an insight into the possible links, existing therapeutics and clinical trials of anti diabetic drugs in patients suffering from AD primarily or as co-morbidity. It may be concluded that the possible beneficial effects and usefulness of the current anti diabetic drugs in AD cannot be neglected and further research is required to achieve positive results. Currently, several drug trials are in progress to give conclusive evidence based data.

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Published

2015-05-19

How to Cite

Rizvi, S. M. D., Shaikh, S., Waseem, S. M. A., Shakil, S., Abuzenadah, A. M., Biswas, D., … Kamal, M. A. (2015). Role of anti-diabetic drugs as therapeutic agents in Alzheimer’s disease. EXCLI Journal, 14, 684–696. https://doi.org/10.17179/excli2015-252

Issue

Vol. 14 (2015)

Section

Review articles

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