How different viruses perturb host cellular machinery via short linear motifs

Authors

  • Sobia Idrees Centre for Inflammation, Centenary Institute and the University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, New South Wales, Australia; E-mail: sobia.idrees@uts.edu.au https://orcid.org/0000-0001-8512-7593
  • Keshav Raj Paudel Centre for Inflammation, Centenary Institute and the University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, New South Wales, Australia https://orcid.org/0000-0002-3591-2080
  • Tayyaba Sadaf Centre for Inflammation, Centenary Institute and the University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, New South Wales, Australia https://orcid.org/0000-0002-0955-6334
  • Philip M. Hansbro Centre for Inflammation, Centenary Institute and the University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, New South Wales, Australia https://orcid.org/0000-0002-4741-3035

DOI:

https://doi.org/10.17179/excli2023-6328

Keywords:

virus, Protein-Protein Interaction, short linear motifs, mimicry

Abstract

The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the host protein's binding partner and interferes with the host protein's pathways. Being opportunistic, viruses have evolved to manipulate host cellular mechanisms by mimicking short linear motifs. In this review, we shed light on the current understanding of mimicry via short linear motifs and focus on viral mimicry by genetically different viral subtypes by providing recent examples of mimicry evidence and how high-throughput methods can be a reliable source to study SLiM-mediated viral mimicry.

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Published

2023-10-26

How to Cite

Idrees, S., Paudel, K. R., Sadaf, T., & Hansbro, P. M. (2023). How different viruses perturb host cellular machinery via short linear motifs. EXCLI Journal, 22, 1113–1128. https://doi.org/10.17179/excli2023-6328

Issue

Vol. 22 (2023)

Section

Review articles

Categories

License

Copyright (c) 2023 Sobia Idrees, Keshav Raj Paudel, Tayyaba Sadaf, Philip M. Hansbro

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