Rhoifolin: A promising flavonoid with potent cytotoxic and anticancer properties
molecular mechanisms and therapeutic potential
DOI:
https://doi.org/10.17179/excli2024-7836Keywords:
Rhoifolin, apigenin-7-O-neohesperidoside, flavonoid, Citrus, anti-cancer activityAbstract
Rhoifolin is a flavonoid found in various plant species, especially within the Rutaceae family, and is considered a dietary component due to its presence in edible plants. Its bioactive properties, such as cytotoxic and anticancer activities, have gained significant attention. This review aims to highlight the general properties and diverse bioactivities of rhoifolin, with a particular focus on its cytotoxic and anticancer effects. This is based on a comprehensive literature search, focusing on the presence of rhoifolin in different plant species and its biological activities, particularly its anticancer properties. Rhoifolin is widely distributed in the plant kingdom, especially in Citrus species. It exhibits a variety of bioactivities, including strong cytotoxic and anticancer effects. Recent studies have shown that rhoifolin can induce apoptosis and inhibit cancer cell proliferation, making it a promising candidate for anticancer therapies. Rhoifolin's diverse bioactivities, particularly its cytotoxic and anticancer properties, position it as a potential therapeutic agent. Further detailed investigations into its molecular mechanisms and well-designed clinical studies are needed to fully understand and utilize its therapeutic potential.
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Copyright (c) 2025 Ceyda Sibel Kılıç, Mehmet Murat Kışla, Gülin Amasya, Ceyda Tuğba Şengel-Türk, Zeynep Ateş Alagöz, Ayşe Mine Gençler Özkan, İlker Ateş, Safa Gümüşok, Jesús Herrera-Bravo, Javad Sharifi-Rad, Daniela Calina
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