Vol. 25 (2026)

Published continuously

Published: 2026-01-02

Original articles

Short-term pretreatment with deferoxamine enhances the in vivo vascularization capacity of nanofat seeded onto dermal substitutes

Valeria Pruzzo, Francesca Bonomi, Ettore Limido, Andrea Weinzierl, Yves Harder, Matthias W. Laschke

621-637
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Genetic diagnosis and molecular characterization of three novel variations in the phenylalanine hydroxylase gene from Chinese patients with phenylketonuria

Fan Yang, Hua-Feng Li, Wei-Jia Tang, Jin-Ping Zhu, Ji-Gang Qiu, Tian-E. Cai, Li-Mei Yu, Ying Yu

458-475
Comparison of LDH activity and LDH-M to predict death in patients with acetaminophen-induced acute liver failure

Debasree Bhadra, Jody A. Rule, William M. Lee, Mitchell R. McGill

330-338
Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice

Pengcheng Zhou, Mohammad Majd Hammour, Romina H. Aspera-Werz, Sabrina Ehnert, Maiju Myllys, Zaynab Hobloss, Reham Hassan, Daniela González, Rama Hendawi, Karolina Edlund, Sandra Hans, Matthias W. Laschke, Ahmed Ghallab, Jan G. Hengstler, Andreas Nüssler, Tanja C. Maisenbacher

290-309
Candesartan cilexetil as a repurposed therapeutic candidate for nasopharyngeal carcinoma: Integrated in vitro and in silico analyses

Chawalit Ngernsombat, Utid Suriya, Somsiri Udompaisarn, Natta Panomchoeng, Tavan Janvilisri

204-221
Real-world data of tirzepatide in obesity management: a multicenter study by the Italian Society of Obesity – Campania Region

Luigi Barrea, Ludovica Verde, Martina Galasso, Renato Patrone, Lucia Digitale, Alessandro Limardi, Marcello Orio, Giovanni Ragozzino, Luigi Digitale, Vittorio Salvatore, Antonella Savoia, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri

191-203
A cross-sectional exploratory study of rat sarcoma (Ras) activation in non-obese women with and without polycystic ovary syndrome

Sara Anjum Niinuma, Haniya Habib, Ashleigh Suzu-Nishio Takemoto, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler

174-185
RNA-Seq-based investigation of interferon-mediated antiviral activity of chlorophyll a from Tetraselmis sp.

Nalae Kang, Eun-A. Kim, Yeon-Ji Lee, Seong-Yeong Heo, Jun-Ho Heo, Won-Kyu Lee, Yong-Kyun Ryu, Taeho Kim, Soo-Jin Heo

150-166
Neurotoxicity of mancozeb-based commercial fungicide in human neuroblastoma SH-SY5Y cells

Evelin G. Cuadros-Buenaventura, Lenin Javier Ramírez-Cando, Ronny Alexander Ordoñez Sánchez, Johnny Chimborazo, Santiago Ballaz

133-149
Metabolic profiling reveals potential biomarkers and underlying signaling pathways involved in mindfulness-based cognitive therapy-improved adolescent depression symptoms

Chun-Hua Xu, Bi-Lan Zhang, Chun-Lan Guan, Lin Wang, Shan Chao, He Li, Qiu-Ping Wu, Da-Jin Zhou, Guo-Qing Min, Fan Yang

68-101
Methyl linolenate suppresses the growth and proliferation of Ehrlich ascites carcinoma (EAC) cells by inducing intrinsic mitochondrial apoptosis

Azmin Akter, Tasnima Kamal, M. Matakabbir Hossain, Abdul Auwal, Khan Mohammad Rashel, Tasfik Ul Haque Pronoy, Asmaulhusna Biswas, Sharmin Akter, Mahmud Ismail, M. Rowshanul Habib, Farhadul Islam

50-67
Computational analysis of hub genes associated with sarcopenia: integrative transcriptome insights from an Asian cohort

Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Min-Jee Kwon, Chiranjib Chakraborty, Jin-Chul Kim, Holger Jahr, Sang-Soo Lee

18-34
IL-8 and follicular fluid: insights into the mechanisms of endometriosis development

Anne Teresa Heinrich, Ada Leoni Terres-Wurtz, Elisa Vacca, Katrin E. Tagscherer, Bartosz Linek, Susanne Gebhard, Annette Hasenburg, Walburgis Brenner, Roxana Schwab

1-17

Review articles

Bidirectional relationship between metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

Alessandro Mantovani, Riccardo Morandin, Nicoletta Rolli, Elisa Molinaroli, Giovanni Targher

803-821
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Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures

Carina O. Walowski, Kristina Norman

776-798
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Hypertension and left ventricular geometry: Diagnosis, prognosis, and management

Samantha M. Mutai, Namrata Kadambi, Mattin Moazzam, Ahmet Afşin Oktay

756-775
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Nanotechnology-driven delivery of dexamethasone for arthritis: The role of liposomes

Kajal Kumari, Anil Pareek, Swapnil Sharma, Sachin Sharma, Vipin Saini, Shadma Wahab, Devesh U. Kapoor

725-755
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Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns

Ligia J. Dominguez, Nicola Veronese, Francesco Saverio Ragusa, Flavia Seminara, Salvatore Maria Baio, Laura Vernuccio, Giuseppina Catanese, Mario Barbagallo

690-724
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Curcumin-loaded nanocarriers for dermatological applications: current advances and biomedical implications

Tanuj Sharma, Jagdeep Singh, Vishal Sharma, Diksha Sharma, Rina Das, Dinesh Kumar Mehta, Isha Chawla, Sonia Yadav, Shivani Chopra, Hitesh Chopra, Jai Bharti Sharma

654-689
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Restoring leptin sensitivity in metabolic and extra-metabolic leptin resistance: Pharmacologic strategies, systemic implications, and future directions

Milan Obradovic, Sara Khodahemmati, Sonja Zafirovic, Esma R. Isenovic

640-653
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The New York City Marathon: A systematic review of performance, participation, pacing, and health-related outcomes

Beat Knechtle, Mabliny Thuany, Pantelis T. Nikolaidis, Pedro Forte, Luciano Bernardes Leite, Romuald Lepers, Daniela Chlíbková, Katja Weiss, Thomas Rosemann, Rodrigo L. Vancini, Sasa Duric

591-620
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TGF-beta inhibitors in cancer therapy: a review of the TGF-beta signal transduction pathway and current developments

Shun-Ban Tai, Jenq-Lin Yang, Pei-Feng Liu, Chun-Lin Chen

550-586
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Modulation of ion channels as emerging therapeutic targets in the treatment of diabetic neuropathy

Tanya Gupta, Alimam Ansari, Rishabh Chalotra, Abhitinder Kumar, Thakur Gurjeet Singh, Randhir Singh

511-549
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The major toxins of Bacillus cereus – Current knowledge on distribution, regulation and mechanism of action

Manar Albahri, Nadja Jessberger

481-510
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Circadian clock regulation in lung health and disease: molecular mechanisms and therapeutic opportunities

Prabesh Baniya, Swekriti Puri, Nisha Panth, Rajan Thapa, Madhu Gupta, Sachin Kumar Singh, Rohit Bhatia, Gaurav Gupta, Kamal Dua, Keshav Raj Paudel

427-457
Paracetamol in pregnancy: Navigating clinical uncertainty and avoiding the communication pitfalls of the “measles, mumps, and rubella” - autism controversy: A narrative review

Helmi Ben Saad, Chamseddine Barki, Ismail Dergaa, Wissem Dhahbi, Halil İbrahim Ceylan, Nasr Chalghaf, Abdelfatteh EL Omri, Hanene Boussi Rahmouni

400-426
MAGEB16 as an epigenetic timing regulator linking X-chromosome biology to neurodevelopmental vulnerability in Autism Spectrum Disorder

John Antonydas Gaspar, Krishnan M. Dhandapani, David C. Hess

377-386
The compartmentalization model of nitrate homeostasis: Role of the salivary glands, skeletal muscle, and liver

Asghar Ghasemi, Sajad Jeddi, Khosrow Kashfi

345-371
Efficacy and safety of CTLA-4, PD-1 and LAG-3 immune checkpoint inhibitors as monotherapy and combination therapy in advanced melanoma: A systematic review and meta-analysis

Osama Omar Khan

310-329
Bridging pathologies: Mechanistic insights into the diabetes–Alzheimer's nexus

Aniket Kakkar, Harpreet Singh, Yash Jasoria, Arvind Kumar, Shivani Chopra, Hitesh Chopra, Arun Kumar Mishra

261-289
Epigenetic regulation of PANoptosis: DNA methylation, histone modifications and non-coding RNAs

Yogendra Singh, Muhammad Afzal, M. Arockia Babu, Surya Nath Pandey, Arcot Rekha, Gaurav Gupta, Imran Kazmi, Sami I. Alzarea, Omar Awad Alsaidan, Waleed Hassan Almalki, Salem Salman Almujri

238-260
Eugenol: A promising therapeutic terpenoid against ischemia-reperfusion injury

Puneet Kaur Randhawa, Deepti Gupta, Mohd Hanifa, Bivek Bajgai, Sorabh Sehajpal, Sarbeshwar Jaggi, Anjana Bali

222-237
Development of nanoparticle-based Toll-like receptor agonists for respiratory immunotherapy

Amisha S. Raikar, Ananya Verma, Mayuri B. Naik, Sweta M. Prabhu, Keshav Raj Paudel, Kamal Dua

102-130

Case reports

The hidden path of mycobacterium: a case series of rare and elusive manifestations of gastrointestinal tuberculosis

Nitika Yadav, Abhishek Yadav, Neharica Joshi, Shubhangi Gupta, Yashendra Sethi

35-49

Letters to the editor

Picroside III: novel multifunctional iridoid glycoside with promising antileukemic activity

Chang Ha Park

799-802
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Triterpenoid saponins and ferroptosis: A membrane centered perspective

Tae Kyung Hyun

822-823
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Reconsidering the advisor–advisee relationship: Beyond the dichotomy between rigor and abuse in graduate education

Jussara Secundo Dos Santos

638-639
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Linking primary cilia defects to the “Big 3” neurodegenerative diseases — causal, consequential, or correlative?

Catherine Hong Huan Hor, Bor Luen Tang

587-590
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Second reply to the second letter to the editor by Alessandria, Berrino, Malatesta and Donzelli (doi: 10.17179/excli2026-9442)

Lamberto Manzoli, Cecilia Acuti Martellucci, Maria Elena Flacco

479-480
Reply to the letter to the editor by Manzoli, Acuti Martelucci and Flacco (doi: 10.17179/excli2025-9176)

Marco Alessandria, Franco Berrino, Giovanni M. Malatesta, Alberto Donzelli

476-478
Marine algae as emerging therapeutics in lung health

Prisca Deviani Pakan, Kiruthika Narayanan, Dennis Chang, Keshav Raj Paudel, Kamal Dua

396-399
Polymorphism engineering of mefenamic acid for enhanced pharmacokinetic performance

Parteek Prasher, Mousmee Sharma

390-395
Cornered professors, a fragilized model, and graduate training… who holds it together?

Mairim R. Serafini, Lucindo J. Quintans-Júnior

387-389
Plant extracts: a potential approach to combating multidrug-resistant bacteria

Sun Sik Kong, Chang Ha Park

372-374
Acetylsalicylic acid versus clopidogrel in cardiovascular prevention: Does the classic still outperform the contemporary?

Ian Jhemes Oliveira Sousa, Kerolayne de Melo Nogueira

342-344
Beyond the pitch: The unaddressed challenges of inadequate uniforms in women's football

Rizia Rocha-Silva, Geovana José, Marília Santos Andrade, Claudio Andre Barbosa de Lira

339-341
On the prenatal origins of the myeloproliferative neoplasms

Stephen E. Langabeer

189-190
Ethnicity matters: The case for regional reference intervals in polycystic ovary syndrome (PCOS) diagnostics

Pallav Sengupta, Sulagna Dutta

186-188
Redefining the role of exercise: beyond medicine and polypill

Kayvan Khoramipour, Susana López-Ortiz, Alejandro Santos-Lozano

170-173
Semaglutide and tirzepatide: Oral cavity effects of weight-loss therapies

Maria Eduarda Bernardo, Felipe Gomes Dallepiane, Mario Escobar, Ariadne Cristiane Cabral Cruz, Cesar Augusto Magalhães Benfatti

167-169
Why does the world continue to struggle with effectively addressing hepatitis E?

Henrique Borges da Silva Grisard, Gislaine Fongaro

131-132

Corrigenda

Corrigendum "Exosomes derived from human mesenchymal stem cells preserve mouse islet survival and insulin secretion function"

Somayeh Keshtkar, Maryam Kaviani, Fatemeh Sabet Sarvestani, Mohammad Hossein Ghahremani, Mahdokht Hossein Aghdaei, Ismail H. Al-Abdullah, Negar Azarpira

375-376