Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases: a meta-analysis of 74 studies with 86,229 subjects

Authors

  • Thelma Beatriz González-Castro Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico
  • Yazmín Hernández-Díaz Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico
  • Nonanzit Pérez-Hernández Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Carlos Alfonso Tovilla-Zárate Multidisciplinary Academic Division of Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, Mexico
  • Isela Esther Juárez-Rojop Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
  • María Lilia López-Narvaez General Hospital de Yajalón Manuel Velasco Siles, Secretaría de Salud, Yajalón, Chiapas, Mexico
  • Ruben Blachman-Braun Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Rosalinda Posadas-Sánchez Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Gilberto Vargas-Alarcón Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Esbeidy García-Flores Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Benny Giovanni Cazarín-Santos Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Verónica Marusa Borgonio-Cuadra Department of Genetics, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
  • Pedro A. Reyes-López Division of Research, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • José Manuel Rodríguez-Pérez Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez. Juan Badiano No. 1, Col Sección XVI, Tlalpan 14080, Mexico City, Mexico. Tel: (+52-55) 55732911, Ext: 26301, E-mail: josemanuel_rodriguezperez@yahoo.com.mx

DOI:

https://doi.org/10.17179/excli2019-1248

Keywords:

IL-6, inflammation, polymorphism, cardiovascular diseases, meta-analysis, genetic association

Abstract

Cardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 (IL-6) gene polymorphisms have been associated with several components of the CVD. Thus, in this study, we thoroughly reviewed and meta-analyzed evidence on the association between the IL-6 (rs1800795) gene polymorphism and CVD. We systematically searched in the PubMed, Web of Sciences, and Scopus databases. The analyses were performed using five study groups based on (1) a combined pool of the overall populations, (2) the country of birth, (3) the continent of birth, (4) the diagnosis and (5) both location (country or continent) and diagnosis. The analysis included the allelic, homozygote, heterozygote, dominant and recessive models. The meta-analysis showed that -174G>C (rs1800795) is a risk factor for CVD (allelic: OR=1.06, CI 95%=1.02-1.10. Z p value <0.0001; homozygous: OR=1.11, CI 95%=1.03-1.19, Z p value= 0.002; heterozygous: OR=1.08, CI 95%=1.03-1.21, Z p value= 0.003; dominant: OR= 1.12, CI 95%= 1.07-1.18, Z p value= 0.001) and that this risk increases in the Chinese population. Additionally, we found that carriers of the C allele of 174G>C (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. Using robust data, we found that IL-6 (rs1800795) -174G>C gene polymorphism is associated with CVD risk.

Published

2019-06-07

How to Cite

González-Castro, T. B., Hernández-Díaz, Y., Pérez-Hernández, N., Tovilla-Zárate, C. A., Juárez-Rojop, I. E., López-Narvaez, M. L., … Rodríguez-Pérez, J. M. (2019). Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases: a meta-analysis of 74 studies with 86,229 subjects. EXCLI Journal, 18, 331–355. https://doi.org/10.17179/excli2019-1248

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Section

Original articles

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