Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury

Authors

  • Siyavash Joukar Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Hamid Najafipour Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Fateme Mirzaeipour Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Hamidreza Nasri Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Mahboubeh Yeganeh Haj Ahmadi Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Marziyeh Badinloo Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

Keywords:

myocardial injury, heart function, arterial blood pressure, isoproterenol, semelil

Abstract

Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3rd day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations.

ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05).

Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.

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Published

2013-02-19

How to Cite

Joukar, S., Najafipour, H., Mirzaeipour, F., Nasri, H., Ahmadi, M. Y. H., & Badinloo, M. (2013). Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury. EXCLI Journal, 12, 122–129. Retrieved from https://www.excli.de/index.php/excli/article/view/1136

Issue

Vol. 12 (2013)

Section

Original articles

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