Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies

Authors

  • Ziya Erdem Koç Department of Chemistry, Faculty of Science, Selçuk University, 42031 Konya, Turkey
  • Mustafa Onur Aladag Vocational School of Health Services, Selçuk University, 42031 Konya, Turkey
  • Ahmet Uysal Vocational School of Health Services, Selçuk University, 42031 Konya, Turkey

Keywords:

cyanuric chloride,dopamine, antimicrobial activity, broth microdilution

Abstract

Two monopodal (2,4-dichloro-6-(3-hydroxytyramine)-1,3,5-triazine) and tripodal (2,4,6-(3-hydroxytyramine)-1,3,5-triazine) s-triazine derivatives were prepared through the reaction of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and 3-hydroxytyramine hydrochloride (dopamine hydrochloride). The structures of the compounds were identified by FT-IR, 1H NMR, 13C NMR, thermal analysis and elemental analysis. Their antimicrobial activities were carried out using the broth microdilution method in dimethyl sulfoxide (DMSO): Phosphate Buffered Saline (PBS) against eight bacteria and one yeast. The results of the test were compared with ampicillin. It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity. These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study. S. aureus was the most sensitive strain against dopamine hydrochloride and E. coli was the most sensitive bacteria against CCDOP1.

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Published

2013-05-07

How to Cite

Koç, Z. E., Aladag, M. O., & Uysal, A. (2013). Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies. EXCLI Journal, 12, 396–403. Retrieved from https://www.excli.de/index.php/excli/article/view/1157

Issue

Vol. 12 (2013)

Section

Original articles

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