Serum Vitamin D levels in patients with chronic kidney disease

Authors

  • Mohd Rozita Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Mohamad Noorul Afidza Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Mustafar Ruslinda Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Rizna Cader Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • A. Gafor Halim Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Chiew Tong Norella Kong Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Kamaruddin Nor Azmi Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  • Shamsul Azhar Shah Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)

Keywords:

25-hydroxyvitamin D, vitamin D insufficiency and deficiency, normal population, CKD patients

Abstract

Introduction: Hypovitaminosis D is reported to be associated with several medical complications. Recent studies have reported a high worldwide prevalence of Vitamin D deficiency in the general population (up to 80 %). This is even higher in patients with chronic kidney disease (CKD) and increases with advancing stages of CKD.

Objectives: To determine the difference in serum Vitamin D [25-hydroxyvitamin D, 25(OH) D] levels between CKD patients and normal healthy population.

Materials and Methods: A prospective cross-sectional study involving 50 normal volunteers (control) and 50 patients with CKD stages 2-4. Their demographic profiles were recorded and blood samples taken for serum 25(OH) D, intact parathyroid hormone (iPTH) and other routine blood tests.

Results: All subjects regardless of renal status had hypovitaminosis D (< 30ng/mL). The mean serum 25(OH) D were comparable in the control and CKD groups (15.3 ± 4.2 ng/mL vs 16.1 ± 6.2 ng/mL, p = NS). However, within the Vitamin D deficient group, the CKD group had lower levels of serum 25(OH) D [12.6(3.7) ng/mL vs 11.2(6.5) ng/mL, p = 0.039]. Female gender [OR 22.553; CI 95 % (2.16-235.48); p = 0.009] and diabetic status [OR 6.456; CI 95 % (1.144-36.433); p = 0.035] were independent predictors for 25(OH) D deficiency.

Conclusions: Vitamin D insufficiency and vitamin D deficiency are indeed prevalent and under-recognized. Although the vitamin D levels among the study subjects and their control are equally low, the CKD group had severe degree of vitamin D deficiency. Diabetic status and female gender were independent predictors of low serum 25(OH)D.

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Published

2013-06-11

How to Cite

Rozita, M., Noorul Afidza, M., Ruslinda, M., Cader, R., Halim, A. G., Kong, C. T. N., … Shah, S. A. (2013). Serum Vitamin D levels in patients with chronic kidney disease. EXCLI Journal, 12, 511–520. Retrieved from https://www.excli.de/index.php/excli/article/view/1167

Issue

Vol. 12 (2013)

Section

Original articles

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