Ethanolic extract of Commiphora mukul gum resin attenuates streptozotocin-induced alterations in carbohydrate and lipid metabolism in rats

Authors

  • B. Ramesh Department of Biochemistry, Sri Venkateswara University, Tirupati - 517502, Andhra Pradesh, India
  • R. Karuna Department of Internal Medicine, University of Nebraska Medical Centre, Omaha, NE, USA
  • S. Sreenivasa Reddy Department of Biochemistry, Sri Krishnadevaraya University, Anantapur - 515003, Andhra Pradesh, India
  • G. Sudhakara Department of Biochemistry, Sri Krishnadevaraya University, Anantapur - 515003, Andhra Pradesh, India
  • D. Saralakumari Department of Biochemistry, Sri Krishnadevaraya University, Anantapur - 515003, Andhra Pradesh, India

Keywords:

C. mukul, diabetes, glycolysis, gluconeogenesis, lipogenesis, tissue lipids

Abstract

The purpose of this study was to investigate the effects of Commiphora mukul gum resin ethanolic extract (CMEEt) administration against altered activities of key enzymes of carbohydrate metabolism, lipid metabolism and changes in glycogen content (liver and muscle) and lipids (liver and heart) in streptozotocin (STZ) induced insulin deficient diabetic Wistar albino rats. Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg body wt) to male Wistar rats. The animals were divided into four groups: Control (C), control-treated (C+CM), diabetic (D) and diabetic-treated group (D+CM). Diabetic-treated and control-treated rats were treated with C. mukul gum resin ethanolic extract (CMEEt) in 2 ml distilled water, orally (200 mg/kg body weight/day for 60 days). At the end of the experimental period, biochemical parameters related to carbohydrate and lipid metabolism were assayed. The significant enhancement in tissue lipids (heart and liver) total cholesterol, triglycerides, phospholipids and free fatty acids of diabetic rats were nearer to normalized in diabetic treated rats (D+CM). Alterations in the activities of enzymes of glucose metabolism (hexokinase, phosphofructokinase, pyruvate kinase, and glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase) and lipid metabolism (fatty acid synthase, malic enzyme and lipoprotein lipase) as observed in diabetic (D) rats were prevented with CMEEt administration. In conclusion, our findings indicate improvement of glucose and lipid metabolisms in STZ induced diabetic rats by treatment with Commiphora mukul and suggest that the plant can be used as an adjuvant for the prevention and/or management of insulin deficiency and disorder related to it.

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Published

2013-06-19

How to Cite

Ramesh, B., Karuna, R., Sreenivasa Reddy, S., Sudhakara, G., & Saralakumari, D. (2013). Ethanolic extract of Commiphora mukul gum resin attenuates streptozotocin-induced alterations in carbohydrate and lipid metabolism in rats. EXCLI Journal, 12, 556–568. Retrieved from https://www.excli.de/index.php/excli/article/view/1173

Issue

Vol. 12 (2013)

Section

Original articles

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