COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)

Authors

  • Aminu Muhammad Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia
  • Hasnah Mohd Sirat Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia

Keywords:

COX-2, Bauhinia rufescens, phytochemicals

Abstract

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC50 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 µM).

Published

2013-09-13

How to Cite

Muhammad, A., & Sirat, H. M. (2013). COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae). EXCLI Journal, 12, 824–830. Retrieved from https://www.excli.de/index.php/excli/article/view/1195

Issue

Section

Original articles