Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower

Authors

  • Min-Jin Kim Cosmetic Center Science, Department of Chemistry, Jeju National University, Ara-1-dong, Jeju 690-756, Korea
  • Kyong-Wol Yang Jeju Love Co., Ltd., 542-5 Haengwon-ri, Gujwa-eup, Jeju 695-975, Korea; Animal Resources Technology, Kyungnam University of Science and Technology, Jinju 660-758, Korea
  • Sang Suk Kim Citrus Research Station, National Institute of Horticulture and Herbal Science, Seogwipo 697-943, Korea
  • Suk Man Park Citrus Research Station, National Institute of Horticulture and Herbal Science, Seogwipo 697-943, Korea
  • Kyung Jin Park Citrus Research Station, National Institute of Horticulture and Herbal Science, Seogwipo 697-943, Korea
  • Kwang Sik Kim Citrus Research Station, National Institute of Horticulture and Herbal Science, Seogwipo 697-943, Korea
  • Young Hun Choi Citrus Research Station, National Institute of Horticulture and Herbal Science, Seogwipo 697-943, Korea
  • Kwang Keun Cho Animal Resources Technology, Kyungnam University of Science and Technology, Jinju 660-758, Korea
  • Nam Ho Lee Cosmetic Center Science, Department of Chemistry, Jeju National University, Ara-1-dong, Jeju 690-756, Korea
  • Chang-Gu Hyun Cosmetic Center Science, Department of Chemistry, Jeju National University, Ara-1-dong, Jeju 690-756, Korea; LINC Agency, Jeju National University, Ara-1-dong, Jeju 690-756, Korea

Keywords:

chemical composition, citrus flower, essential oil, inflammation, Hallabong

Abstract

A number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower [(Citrus unshiu Marcov × Citrus sinensis Osbeck) × Citrus reticulata Blanco] and their anti-inflammatory effects. Hydro-distilled essential oils (HEOs) were analyzed using gas chromatography-mass spectrometry (GC-MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), l-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. HEOs were found to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production and to suppress the LPS-induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β (IC50 values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these results, we suggest that HEOs can be considered potential anti-inflammatory candidates for therapeutic use in humans.

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Published

2013-11-07

How to Cite

Kim, M.-J., Yang, K.-W., Kim, S. S., Park, S. M., Park, K. J., Kim, K. S., … Hyun, C.-G. (2013). Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower. EXCLI Journal, 12, 933–942. Retrieved from https://www.excli.de/index.php/excli/article/view/1204

Issue

Vol. 12 (2013)

Section

Original articles

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