Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt

Authors

  • Adel Abdel-Moneim Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt
  • Basant M. Morsy Biochemistry Division, Chemistry Department, Faculty of Science, Beni-Suef University, Egypt
  • Ayman M. Mahmoud Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt
  • Mohamed A. Abo-Seif Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Egypt
  • Mohamed I. Zanaty Biochemistry Division, Chemistry Department, Faculty of Science, Beni-Suef University, Egypt

Keywords:

Hepatitis C, Nigella sativa, Zingiber officinale, viral load

Abstract

Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer patients with proven HCV and fifteen age matched healthy subjects were included in this study. Exclusion criteria included patients on interferon alpha (IFN-α) therapy, infection with hepatitis B virus, drug-induced liver diseases, advanced cirrhosis, hepatocellular carcinoma (HCC) or other malignancies, blood picture abnormalities and major severe illness. Liver function enzymes, albumin, total bilirubin, prothrombin time and concentration, international normalized ratio, alpha fetoprotein and viral load were all assessed at baseline and at the end of the study. Ethanolic extracts of Nigella sativa and Zingiber officinale were prepared and formulated into gelatinous capsules, each containing 500 mg of Nigella sativa and/or Zingiber officinale. Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. Both extracts as well as their mixture significantly ameliorated the altered viral load, alpha fetoprotein, liver function parameters; with more potent effect for the combined therapy. In conclusion, administration of Nigella sativa and/or Zingiber officinale ethanolic extracts to HCV patients exhibited potential therapeutic benefits via decreasing viral load and alleviating the altered liver function, with more potent effect offered by the mixture.

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Published

2013-11-11

How to Cite

Abdel-Moneim, A., Morsy, B. M., Mahmoud, A. M., Abo-Seif, M. A., & Zanaty, M. I. (2013). Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt. EXCLI Journal, 12, 943–955. Retrieved from https://www.excli.de/index.php/excli/article/view/1205

Issue

Vol. 12 (2013)

Section

Original articles

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