miRNA regulation during cardiac development and remodeling in cardiomyopathy

Authors

  • K.L. Chaitra Department of Genetics, Osmania University, Hyderabad, India
  • Kayalvili Ulaganathan Department of Genetics, Osmania University, Hyderabad, India
  • Anita James Department of Genetics, Osmania University, Hyderabad, India
  • Venkateshwari Ananthapur Institute of Genetics and Hospital for Genetic Diseases, Hyderabad, India
  • Pratibha Nallari Department of Genetics, Osmania University, Hyderabad, India

Keywords:

miRNA, cardiomyopathy, modifiers, signaling pathways

Abstract

miRNAs have been found to play a major role in cardiomyopathy, a heart muscle disorder characterized by cardiac dysfunction. Several miRNAs including those involved in heart development are found to be dysregulated in cardiomyopathy. These miRNAs act either directly or indirectly by controlling the genes involved in normal development and functioning of the heart. Indirectly it also targets modifier genes and genes involved in signaling pathways. In this review, miRNAs involved in heart development, including dysregulation of miRNA which regulate various genes, modifiers and notch signaling pathway genes leading to cardiomyopathy are discussed. A study of these miRNAs would give an insight into the mechanisms involved in the processes of heart development and disease. Apart from this, information gathered from these studies would also generate suitable therapeutic targets in the form of antagomirs which are chemically engineered oligonucleotides used for silencing miRNAs.

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Published

2013-11-26

How to Cite

Chaitra, K., Ulaganathan, K., James, A., Ananthapur, V., & Nallari, P. (2013). miRNA regulation during cardiac development and remodeling in cardiomyopathy. EXCLI Journal, 12, 980–992. Retrieved from https://www.excli.de/excli/article/view/1208

Issue

Vol. 12 (2013)

Section

Review articles

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