Lungs deposition and pharmacokinetic study of submicron budesonide particles in Wistar rats intended for immediate effect in asthma

Authors

  • Abdul Rauf Formulation Research Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
  • Aseem Bhatnagar Department of Nuclear Medicine, Institute of Nuclear Medicine & Allied Sciences (INMAS), Brig. Mazumdar Road, Delhi, India
  • S.S. Sisodia Bhupal Nobles College of Pharmacy, Udaipur, India
  • Roop K. Khar Formulation Research Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
  • Farhan J. Ahmad Formulation Research Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

DOI:

https://doi.org/10.17179/excli2016-845

Keywords:

budesonide, asthma, submicron particles, aerosolization, lungs deposition, pharmacokinetic

Abstract

The purpose of the present investigation was to study the aerosolization, lungs deposition and pharmacokinetic study of inhalable submicron particles of budesonide in male Wistar rats. Submicron particles were prepared by antisolvent nanoprecipitation method and freeze-dried to obtain free flowing powder. The freeze-drying process yielded dry powder with desirable aerodynamic properties for inhalation therapy. An in-house model inhaler was designed to deliver medicine to lungs, optimized at dose level of 10 mg for 30 sec of fluidization. The in vitro aerosolization study demonstrates that submicron particles dissolve faster with improved aerosolization effect as compared to micronized budesonide. Both submicron and micron particles were compared for in vivo lungs deposition. The results showed that relatively high quantity of submicron particles reaches deep into the lungs as compared to micron particles. Most pronounced effect observed with submicron particles from pharmacokinetic parameters was the enhancement in peak plasma concentration (Cmax) by 28.85 %, and increase in area under concentration curve (AUC0-8h) by 30.33 % compared to micron sized particles. The results suggested that developed submicronized formulation of budesonide can be used for pulmonary drug delivery for high deposition to deep lungs tissues.

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Published

2017-03-10

How to Cite

Rauf, A., Bhatnagar, A., Sisodia, S., Khar, R. K., & Ahmad, F. J. (2017). Lungs deposition and pharmacokinetic study of submicron budesonide particles in Wistar rats intended for immediate effect in asthma. EXCLI Journal, 16, 236–244. https://doi.org/10.17179/excli2016-845

Issue

Vol. 16 (2017)

Section

Original articles

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