Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease

Authors

  • Golnaz Ekhlasi Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Mitra Zarrati Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Shahram Agah Colorectal Research Center; Iran University of Medical Sciences, Tehran, Iran
  • Agha Fatemeh Hosseini Department of Math and Statistics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  • Sharieh Hosseini Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran (IAUPS)
  • Shahrzad Shidfar Internist, Worcester Memorial Hospital, University of Massachusetts, Worcester, Massachusetts, U.S.A
  • Seyed Soroush Soltani Aarbshahi Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Elham Razmpoosh Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Farzad Shidfar Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Colorectal Research Center; Iran University of Medical Sciences, Tehran, Iran; Iran National Science Foundation, Tehran, Iran

DOI:

https://doi.org/10.17179/excli2016-846

Keywords:

symbiotic, alpha-tocopherol, blood pressure, nitric oxide, NAFLD

Abstract

Non-alcoholic fatty liver disease (NAFLD) has been suggested to be well correlated with altered blood pressure. This study was conducted to determine the effects of symbiotic and vitamin E supplementation on blood pressure and inflammatory indices of patients with NAFLD. This randomized, double-blind, placebo-controlled trial was performed among 60 NAFLD patients aged 25 to 64 years old. Participants were randomly divided into four groups to receive a 400 IU alpha-tocopherol and 2 × 108 CFU/g symbiotic supplement for 8 weeks. The anthropometric parameters, systolic blood pressure (SBP) and diastolic blood pressure (DBP), serum malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor α (TNFα) were assessed at baseline and after 8 weeks of intervention. After 8 weeks of intervention, combined symbiotic and alpha-tocopherol, symbiotic and alpha-tocopherol alone administration, compared with the placebo, resulted in significant decreases in SBP (-17.07±2.1, -16.07±3.56, -1.73±2.25 and -1.55±3.01 mmHg, P=0.01), serum MDA (-1.19±0.5, -0.12±0.65, 0.14 ± 0.64 and 0.16±0.34 nmol/mL, P<0.001), serum TNFα (-15.62±13.93, -9.24±7.12, -11.44 ± 15.47 and 3.01±1.71 pg/ml, P<0.001) concentrations. A significant decrease in serum AST (-11.36±4.52, -7.43±8.58, -5.93±6.61 and 2.5±5.75 μmol/L, P <0.001), ALT (-12.79±3.65, -3.66±6.81, -6.54±7.66 and 4.16±3.43 μmol/L, P <0.001) and ALP (-26.8±11.1, -4.56±9.22, -14.48±12.22 and 5.19±2.64 μmol/L, P <0.001) was seen. Variations in DBP and serum NO concentration were not significant. Alpha-tocopherol and symbiotic supplementation among patients with NAFLD resulted in decreased SBP, serum MDA, TNFα levels and enzymes liver; however, they did not affect DBP and serum NO concentration.

Published

2017-03-20

How to Cite

Ekhlasi, G., Zarrati, M., Agah, S., Hosseini, A. F., Hosseini, S., Shidfar, S., … Shidfar, F. (2017). Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease. EXCLI Journal, 16, 278–290. https://doi.org/10.17179/excli2016-846

Issue

Section

Original articles