Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis: A meta-analysis

Authors

  • Mohammad Naderi Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Mohammad Hashemi Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  • Hossein Ansari Department of Epidemiology and Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran

DOI:

https://doi.org/10.17179/excli2016-662

Keywords:

MIF, polymorphism, tuberculosis, meta-analysis

Abstract

The aim of the present meta-analysis was to find out the impact of MIF -173 G > C polymorphism on risk of tuberculosis (TB). We conducted a search of case-control studies on the associations of -173 G > C variant of MIF with susceptibility to tuberculosis in PubMed, ISI Web of Science, and Scopus. We extracted the data from eligible studies and achieved a meta-analysis to examine the relationship between MIF -173 G > C polymorphism and the risk of TB. Odds ratios (ORs) with the corresponding 95 % confidence intervals (CIs) were pooled to find out the impact of MIF -173G > C promoter polymorphism on TB risk. The pooled ORs were calculated for the codominant, dominant, recessive, and allelic model comparison. The findings revealed that MIF -173 G > C variant increased the risk of TB in codominant (OR = 1.54, 95 %CI = 1.26-1.88, p < 0.0001; CG vs GG), and dominant (OR = 1.62, 95 %CI = 1.33-1.96, p < 0.00001; GC+CC vs GG) inheritance models tested. The results suggested that the MIF -173 C allele significantly increased the risk of PTB (OR = 1.49, 95 %CI = 1.28-1.74, p < 0.00001). The findings of this meta-analysis propose that MIF -173 G > C variant is associated with the risk of TB. More case-control studies with well-designed in different ethnic groups and larger sample size are needed to confirm the findings.

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Published

2017-03-21

How to Cite

Naderi, M., Hashemi, M., & Ansari, H. (2017). Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis: A meta-analysis. EXCLI Journal, 16, 313–320. https://doi.org/10.17179/excli2016-662

Issue

Vol. 16 (2017)

Section

Original articles

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