The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

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Saeideh Vafa
Shahpar Haghighat
Leila Janani
Ali Saneei Totmaj
Mehraban Navaei
Ali Amirinejad
Hadi Emamat
Zahra Salehi
Mitra Zarrati

Abstract

Breast cancer-related lymphedema (BCRL) is one of the most common complications of breast cancer treatments, which may be exacerbated by obesity. Dysbiosis may negatively impact the management of obesity and lymphedema by increasing inflammation. The objective of this study was to assess the effects of supplementation with synbiotics on inflammatory markers, serum leptin concentration and edema volume in overweight and obese BCRL women following a low-calorie diet (LCD). In a randomized double-blind controlled clinical trial, 88 breast cancer survivors with lymphedema were supplemented once a day for 10 weeks with either a synbiotic or a placebo capsule. Both groups were under a low-calorie diet (LCD). At the end of the study, synbiotic supplementation resulted in a significant reduction in leptin (P=0.003) and TNF-α (P=0.039) between the study groups. Besides, edema volume was significantly reduced within the synbiotic group after the intervention. We did not observe any significant effects of the synbiotic supplementation in hs-CRP, and IL-1β between the study groups (P=0.550, P=0.118 respectively). Conclusively, synbiotic supplementation along with an LCD program in breast cancer survivors with lymphedema had beneficial effects on the concentration of serum inflammatory markers and edema volume.

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How to Cite
Vafa, S., Haghighat, S., Janani, L., Totmaj, A. S., Navaei, M., Amirinejad, A., Emamat, H., Salehi, Z., & Zarrati, M. (2020). The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema. EXCLI Journal, 19, 1-15. https://doi.org/10.17179/excli2019-1876
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Original articles