Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite

Authors

  • Reza Mahmoudi Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  • Zahra Honarmand Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
  • Saied Karbalay-Doust Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mehrzad Jafari-Barmak Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  • Mohsen Nikseresht Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  • Ali Noorafshan Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI:

https://doi.org/10.17179/excli2017-143

Keywords:

curcumin, rat, sodium metabisulfite, stereology, testicle

Abstract

Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respectively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue volume increased (15-20 %) in both groups (P<0.01). Besides, 19-36 % and 41-57 % of the cells (spermatogonia types A and B, spermatids, Sertoli and Leydig) were lost in the rats that received intermediate and high doses of Na-MBS respectively in comparison to the control groups. Nonetheless, all the above-mentioned alterations ameliorated drastically in the rats that received Na-MBS plus CUR compared to those exposed to Na-MBS without CUR therapy (P<0.01). The acceptable daily intake of Na-MBS for 7 weeks did not affect on testicular parameters. CUR (100 mg/kg/day) could prevent structural impairments of testicles in the rats induced by Na-MBS (7 and 70 mg/kg/day).

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Published

2017-04-24

How to Cite

Mahmoudi, R., Honarmand, Z., Karbalay-Doust, S., Jafari-Barmak, M., Nikseresht, M., & Noorafshan, A. (2017). Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite. EXCLI Journal, 16, 583–592. https://doi.org/10.17179/excli2017-143

Issue

Vol. 16 (2017)

Section

Original articles

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