Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet's disease

Authors

  • Aydin Rustemoglu Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey
  • Esra Erkol Inal Suleyman Demirel University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Isparta, Turkey
  • Ahmet Inanir Gaziosmanpasa University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Tokat, Turkey
  • Duygu Ekinci Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey
  • Ulker Gul Akdeniz University, Faculty of Medicine, Department of Dermatology, Antalya, Turkey
  • Serbulent Yigit Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey
  • Omer Ates Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey
  • Nevin Karakus Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey

DOI:

https://doi.org/10.17179/excli2017-189

Keywords:

Behçet's disease, NCOA5, rs2903908, uveitis

Abstract

Behçet's disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor subfamily 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Also, the NCOA5 gene insufficiency leads to an elevated expression of IL-6, and increased levels of IL-6 were found to be related to the pathogenesis of BD. In this study, we aimed to clarify the impact of the NCOA5 rs2903908 polymorphism on susceptibility and clinical findings of BD. This study included 671 participants (300 BD patients and 371 healthy controls). The analyses of NCOA5 rs2903908 polymorphism was performed by using the TaqMan allelic discrimination assay. The frequency of TT genotype of the NCOA5 rs2903908 polymorphism was found significantly higher in BD patients compared to those in healthy controls (p=0.016, OR=1.46, 95 % CI=1.08-1.99). Also, the frequencies of CT genotype was observed significantly higher in BD patients with genital ulceration and uveitis than without genital ulceration and uveitis (p=0.002 and p=0.005, respectively). The most significant association was found between C allele frequencies of BD patients with and without uveitis (p=0.0001). Our study represents for the first time that the NCOA5 rs2903908 polymorphism seemed to be linked to BD susceptibility and clinical findings.

Published

2017-05-04

How to Cite

Rustemoglu, A., Erkol Inal, E., Inanir, A., Ekinci, D., Gul, U., Yigit, S., … Karakus, N. (2017). Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet’s disease. EXCLI Journal, 16, 609–617. https://doi.org/10.17179/excli2017-189

Issue

Section

Original articles