Current biological and pharmacological updates on wogonin

Authors

  • Sarita Rawat School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Gaurav Gupta School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India. E-mail: gauravpharma25@gmail.com
  • Sachchidanand Pathak School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Santosh Kumar Singh School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Himmat Singh School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Anurag Mishra School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Ritu Gilhotra School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
  • Alaa A. A. Aljabali Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid 21163, Jordan
  • Harish Dureja Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India
  • Murtaza M. Tambuwala School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County, Londonderry, BT52 1SA, Northern Ireland, United Kingdom
  • Dinesh K. Chellappan Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia 57000
  • Kamal Dua Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, NSW 2308, Australia

DOI:

https://doi.org/10.17179/excli2020-1967

Keywords:

wogonin, anticancer, antiinflammatory, hepatoprotective

Abstract

Wogonin (5, 7-Dihydroxy-8-methoxyflavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancertherapy and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing heat. Wogonin glycosides  are known as wogonosides. Oroxindin, a wogonin glucuronide isolated from Oroxylum indicum, is one of the example of wogonoside. It is also used in Japanese herbal supplement named Sho-Saiko-To, as an important active ingredient. One of the major active constituents of wogonin, Scutellaria baicalensis, shows potent anticancer activities both in vivo and in vitro studies. The anticancer therapeutic activity of wogonin has been shown by regulation of different cell signaling pathways , which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways. Wogonin also shows positive therapeutic anticancer effects in breast cancer by  inhibiting the 5‑LO/BLT2/ERK/IL‑8/MMP‑9 signaling cascade and established a major pharmacological anticancer activity.

Published

2020-05-13

How to Cite

Rawat, S., Gupta, G., Pathak, S., Singh, S. K., Singh, H., Mishra, A., Gilhotra, R., Aljabali, A. A. A., Dureja, H., Tambuwala, M. M., Chellappan, D. K., & Dua, K. (2020). Current biological and pharmacological updates on wogonin. EXCLI Journal, 19, 635–640. https://doi.org/10.17179/excli2020-1967

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Letters to the editor

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