Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway

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Faiz Ahmad
Amit Sarder
Rajesh Gour
Shibendra Kumar Lal Karna
Priya Arora
P. Ravindranathan Kartha
Yuba Raj Pokharel

Abstract

Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells, which is the second leading cause of death globally. To treat cancer, currently, a number of anticancer drugs belonging to various classes chemically are available. The discovery of artemisinin and its derivatives such as artesunate, arteether, and artemether became a milestone in the cure for malaria. Here, we report the anti-cancer property of anhydrodihydroartemisinin (ADHA) - a semisynthetic derivative of artemisinin against prostate cancer cell line PC-3. ADHA was found to be inhibiting growth of PC-3 cells. ADHA was also found to be inhibiting migration of PC-3 cells. At molecular level, ADHA was found to be inhibiting the expression of c-Jun, p-c-Jun, p-Akt and NF-κB and activated caspase 3 and 7. The results show that ADHA like few other artemisinin derivatives hold potential to be used as an anti-cancer agent against prostate cancer cells.

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How to Cite
Ahmad, F., Sarder, A., Gour, R., Karna, S. K. L., Arora, P., Kartha, P. R., & Pokharel, Y. R. (2020). Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway. EXCLI Journal, 19, 613-619. https://doi.org/10.17179/excli2020-1331
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Original articles

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