Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Authors

  • Norhashima Abd Rashid Center for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Farida Hussan Human Biology Department, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
  • Asmah Hamid Centre for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Nurul Raudzah Adib Ridzuan Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia
  • Syarifah Aisyah Syed Abdul Halim Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Nahdia Afiifah Abdul Jalil Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Nor Haliza Mohamad Najib Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Seong Lin Teoh Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Siti Balkis Budin Center for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. E-mail: balkis@ukm.edu.my

DOI:

https://doi.org/10.17179/excli2020-2355

Keywords:

apoptosis, cisplatin, hepatotoxicity, inflammation, Polygonum minus essential oil, oxidative stress

Abstract

Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and all animals were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1 and indicators of oxidative stress including malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status (glutathione, glutathione peroxidase, superoxide dismutase and catalase) as compared to cisplatin group. PmEO100CP pretreatment also  modulated changes in liver inflammatory markers (TNF-α, IL-1α, IL-1β, IL-6 and IL-10). PmEO100CP administration also notably reduced cisplatin-induced apoptosis significantly as compared to cisplatin group. In conclusion, our results suggested that P. minus essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis.

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Published

2020-09-09

How to Cite

Abd Rashid, N., Hussan, F., Hamid, A., Adib Ridzuan, N. R., Halim, S. A. S. A., Abdul Jalil, N. A., … Budin, S. B. (2020). Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways. EXCLI Journal, 19, 1246–1265. https://doi.org/10.17179/excli2020-2355

Issue

Vol. 19 (2020)

Section

Original articles

License

Copyright (c) 2020 Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Syarifah Aisyah Syed Abdul Halim, Nahdia Afiifah Abdul Jalil, Nor Haliza Mohamad Najib, Seong Lin Teoh, Siti Balkis Budin

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