Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women

Authors

  • Moushira Zaki Biological Anthropology Department, National Research Centre, Cairo, Egypt
  • Sanaa Kamal Biological Anthropology Department, National Research Centre, Cairo, Egypt
  • Shams Kholousi Immunogenetics Department, Human Genetics and Genome Research Division, National Research Centre, Giza, Egypt
  • Hala T. El-Bassyouni Clinical Genetics Department, National Research Centre, Cairo, Egypt
  • Walaa Yousef Biological Anthropology Department, National Research Centre, Cairo, Egypt
  • Hanaa Reyad Biological Anthropology Department, National Research Centre, Cairo, Egypt
  • Ramy Mohamed Biological Anthropology Department, National Research Centre, Cairo, Egypt
  • Walaa A. Basha Biological Anthropology Department, National Research Centre, Cairo, Egypt

DOI:

https://doi.org/10.17179/excli2017-275

Keywords:

metabolic parameters, advanced glycation end products, RAGE, obese women

Abstract

Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aimed to explore the serum levels of sRAGE in Egyptian obese women and compare with healthy non-obese controls and investigate the relationship between serum sRAGE, metabolic parameters, and obesity complications. The soluble form of receptor for advanced glycation end products (sRAGE), anthropometry, metabolic and biochemical biomarkers were measured in 100 obese women and 100 age-matched healthy control non-obese women. The homeostasis model assessment estimate of insulin resistance (HOMA-IR) has been determined from serum insulin and glucose values. Serum sRAGE levels were significantly lower in obese cases than controls and inversely correlated with obesity and metabolic parameters. Results of univariate and multivariate analyses for determinants of serum sRAGE levels in obese cases showed that parameters statistically and significantly related were body mass index (BMI), waist circumference (WC), LDL-C, TG, BP, HOMA-IR, ALT and AST. sRAGE is a novel biomarker for metabolic dysfunction in Egyptian obese women and might predict the future cardio-metabolic events.

Downloads

Published

2017-06-29

How to Cite

Zaki, M., Kamal, S., Kholousi, S., El-Bassyouni, H. T., Yousef, W., Reyad, H., … Basha, W. A. (2017). Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women. EXCLI Journal, 16, 973–980. https://doi.org/10.17179/excli2017-275

Issue

Vol. 16 (2017)

Section

Original articles

License

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).