Microfluidics as efficient technology for the isolation and characterization of stem cells

Isolation and characterization of stem cells by microfluidics

Authors

  • Afsoon Aghlmandi Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
  • Aylin Nikshad Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
  • Reza Safaralizadeh Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran https://orcid.org/0000-0002-6970-6998
  • Majid Ebrahimi Warkiani The School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia https://orcid.org/0000-0002-4184-1944
  • Leili Aghebati-Maleki Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. E-mail: leili_aghebati_maleki@yahoo.com https://orcid.org/0000-0002-0044-5961
  • Mehdi Yousefi Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98-4133364665; Fax: +98-4133364665; E-mail: yousefime@tbzmed.ac.ir https://orcid.org/0000-0003-0099-6728

DOI:

https://doi.org/10.17179/excli2020-3038

Keywords:

stem cell, cell isolation

Abstract

The recent years have been passed with significant progressions in the utilization of microfluidic technologies for cellular investigations. The aim of microfluidics is to mimic small-scale body environment with features like optical transparency. Microfluidics can screen and monitor different cell types during culture and study cell function in response to stimuli in a fully controlled environment. No matter how the microfluidic environment is similar to in vivo environment, it is not possible to fully investigate stem cells behavior in response to stimuli during cell proliferation and differentiation. Researchers have used stem cells in different fields from fundamental researches to clinical applications. Many cells in the body possess particular functions, but stem cells do not have a specific task and can turn into almost any type of cells. Stem cells are undifferentiated cells with the ability of changing into specific cells that can be essential for the body. Researchers and physicians are interested in stem cells to use them in testing the function of the body’s systems and solving their complications. This review discusses the recent advances in utilizing microfluidic techniques for the analysis of stem cells, and mentions the advantages and disadvantages of using microfluidic technology for stem cell research.

Author Biography

Mehdi Yousefi, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98-4133364665; Fax: +98-4133364665; E-mail: yousefime@tbzmed.ac.ir

Mehdi_Yousefi@gmail.com (diese email funktioniert nicht)

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Published

2021-02-22

How to Cite

Aghlmandi , A. ., Nikshad , A. ., Safaralizadeh, R. ., Warkiani, M. E., Aghebati-Maleki, L., & Yousefi, M. . (2021). Microfluidics as efficient technology for the isolation and characterization of stem cells: Isolation and characterization of stem cells by microfluidics. EXCLI Journal, 20, 426–443. https://doi.org/10.17179/excli2020-3038

Issue

Vol. 20 (2021)

Section

Review articles

License

Copyright (c) 2021 Afsoon Aghlmandi , Aylin Nikshad , Reza Safaralizadeh, Majid Ebrahimi Warkiani, Leili Aghebati-Maleki, Mehdi Yousefi

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