A review on function and side effects of systemic corticosteroids used in high-grade COVID-19 to prevent cytokine storms

Main Article Content

Mohammad Amin Langarizadeh
Marziye Ranjbar Tavakoli
Ardavan Abiri
Ali Ghasempour
Masoud Rezaei
Alieh Ameri

Abstract

In December 2019, a cluster of pneumonia caused by a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, Hubei province, China. Cytokine storm is an uncontrolled systemic inflammatory response resulting from the release of large amounts of pro-inflammatory cytokines and chemokines that occurs at phase 3 of viral infection. Such emergence led to the development of many clinical trials to discover efficient drugs and therapeutic protocols to fight with this single-stranded RNA virus. Corticosteroids suppress inflammation of the lungs during the cytokine storm, weaken immune responses, and inhibit the elimination of pathogen. For this reason, in COVID-19 corticosteroid therapy, systemic inhibition of inflammation is observed with a wide range of side effects. The present review discusses the effectiveness of the corticosteroid application in COVID-19 infection and the related side effects of these agents. In summary, a number of corticosteroids, including and especially methylprednisolone and dexamethasone, have demonstrated remarkable efficacy, particularly for COVID-19 patients who underwent mechanical ventilation.

Article Details

How to Cite
Langarizadeh , M. A. ., Ranjbar Tavakoli , M. ., Abiri , A. ., Ghasempour , A. ., Rezaei , M. ., & Ameri, A. (2021). A review on function and side effects of systemic corticosteroids used in high-grade COVID-19 to prevent cytokine storms . EXCLI Journal, 20, 339-365. https://doi.org/10.17179/excli2020-3196
Section
Review articles