Molecular pathways in the development of HPV-induced cervical cancer

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Farnaz Rasi Bonab
Amir Baghbanzadeh
Moslem Ghaseminia
Nadia Bolandi
Ahad Mokhtarzadeh
Mohammad Amini
Kianoosh Dadashzadeh
Khalil Hajiasgharzadeh
Behzad Baradaran
Hossein Bannazadeh Baghi


Recently, human papillomavirus (HPV) has gained considerable attention in cervical cancer research studies. It is one of the most important sexually transmitted diseases that can affect 160 to 289 out of 10000 persons every year. Due to the infectious nature of this virus, HPV can be considered a serious threat. The knowledge of viral structure, especially for viral oncoproteins like E6, E7, and their role in causing cancer is very important. This virus has different paths (PI3K/Akt, Wnt/β-catenin, ERK/MAPK, and JAK/STA) that are involved in the transmission of signaling paths through active molecules like MEK (pMEK), ERK (pERK), and Akt (pAkt). It’s eventually through these paths that cancer is developed. Precise knowledge of these paths and their signals give us the prognosis to adopt appropriate goals for prevention and control of these series of cancer.

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Rasi Bonab, F., Baghbanzadeh, A., Ghaseminia, M., Bolandi, N., Mokhtarzadeh, A., Amini, M., Dadashzadeh, K., Hajiasgharzadeh, K., Baradaran, B., & Bannazadeh Baghi, H. (2021). Molecular pathways in the development of HPV-induced cervical cancer. EXCLI Journal, 20, 320-337.
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