EXCLI J EXCLI Journal 1611-2156 Leibniz Research Centre for Working Environment and Human Factors 2015-664 10.17179/excli2015-664 Doc1 Letter to the editor An update on the potential health benefits of carotenes Kim Jae Kwang * 1 Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, Korea *To whom correspondence should be addressed: Jae Kwang Kim, Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, Korea; Phone: +82-32-835-8241, Fax: +82-32-835-0763, E-mail: kjkpj@inu.ac.kr 06 01 2016 2016 15 1 4 03 11 2015 07 12 2015 Copyright © 2016 Kim 2016

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Dear Editor,

Carotenes, which are yellow-orange pigments, are a class of related organic compounds classified as hydrocarbons, more specifically as terpenoids, with the molecular formula C40H56. Plants, fungi, and photosynthetic bacteria synthesize carotenes, while animals must obtain them as a dietary nutrient (Vrolijk et al., 2015[30]). Plants are capable of synthesizing several isomers of carotene. Alpha-carotene (α-carotene) and beta-carotene (β-carotene) are the two primary isomers found in plants; other carotene isomers found in plants are gamma-, delta-, epsilon-, and zeta-carotene (γ, δ, ε, and ζ-carotene) (Hammond and Renzi, 2013[9]). β-Carotene is the most common form of carotene in plants and can be found in yellow, orange, and green leafy vegetables and fruits. It is an important dietary resource and a precursor of vitamin A in humans (Haskell, 2012[12]; Tang, 2012[29]; Sommer and Vyas, 2012[28]).

Carotenes show a range of biological activity and health benefits for animals, making it an interesting material for the pharmaceutical, food, and cosmetics industries. We have reviewed the most recent studies on carotenes and its biological and pharmacological activities (Table 1(Tab. 1)) (References in Table 1: Li et al., 2015[17]; Freitas et al., 2015[7]; Sluijs et al., 2015[27]; Hashim et al., 2015[11]; Das et al., 2015[5]; Ben Amara et al., 2015[2]; Schnorr et al., 2014[25]; Fiorelli et al., 2014[6]; Lai et al., 2014[15]; Kasperczyk et al., 2014[13]; Lim et al., 2014[18]; Wang et al., 2014[31]; Kim et al., 2014[14]; Berti et al., 2014[3]; Gloria et al., 2014[8]; Orazizadeh et al., 2014[22]; Abdul-Hamid and Moustafa, 2014[1]; Nishida et al., 2014[21]; Harari et al., 2013[10]; Bjelakovic et al., 2013[4]; Lee et al., 2013[16]; Lin et al., 2013[20]; Rotenstreich et al., 2013[24]; Silva et al., 2013[26]; Lim et al., 2013[19]; Peng et al., 2013[23]).

Acknowledgements

This work was supported by the Incheon National University Research Grant in 2013.

Abdul-Hamid M Moustafa N Amelioration of alloxan-induced diabetic keratopathy by beta-carotene Exp Toxicol Pathol 2014 66 49 59 Ben Amara N Tourniaire F Maraninchi M Attia N Amiot-Carlin MJ Raccah D Independent positive association of plasma β-carotene concentrations with adiponectin among non-diabetic obese subjects Eur J Nutr 2015 54 447 454 Berti AP Düsman E Mariucci RG Lopes NB Vicentini VE Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats Genet Mol Res 2014 13 2248 2258 Bjelakovic G Nikolova D Gluud C Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One 2013 8 e74558 Das R Das A Roy A Kumari U Bhattacharya S Haldar PK β-carotene ameliorates arsenic-induced toxicity in albino mice Biol Trace Elem Res 2015 164 226 233 Fiorelli SK Vianna LM Oliveira CA Fiorelli RK Barros BC Almeida CR The effects of supraphysiological supplementation of β-carotene in spontaneously hypertensive rats (SHR and SHR-sp) Rev Col Bras Cir 2014 41 351 355 Freitas JV Praça FS Bentley MV Gaspar LR Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters Int J Pharm 2015 484 131 137 Gloria NF Soares N Brand C Oliveira FL Borojevic R Teodoro AJ Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines Anticancer Res 2014 34 1377 1386 Hammond BR Jr Renzi LM Carotenoids Adv Nutr 2013 4 474 476 Harari A Abecassis R Relevi N Levi Z Ben-Amotz A Kamari Y Prevention of atherosclerosis progression by 9-cis-β-carotene rich alga Dunaliella in apoE-deficient mice Biomed Res Int 2013 2013 169517 Hashim D Gaughan D Boffetta P Lucchini RG Baseline serum β-carotene concentration and mortality among long-term asbestos-exposed insulators Cancer Epidemiol Biomarkers Prev 2015 24 555 560 Haskell MJ The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion--evidence in humans Am J Clin Nutr 2012 96 1193S 1203S Kasperczyk S Dobrakowski M Kasperczyk J Romuk E Prokopowicz A Birkner E The influence of beta-carotene on homocysteine level and oxidative stress in lead-exposed workers Med Pr 2014 65 309 316 Kim YS Lee HA Lim JY Kim Y Jung CH Yoo SH β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α J Nutr Biochem 2014 25 655 664 Lai GY Weinstein SJ Taylor PR McGlynn KA Virtamo J Gail MH Effects of α-tocopherol and β-carotene supplementation on liver cancer incidence and chronic liver disease mortality in the ATBC study Br J Cancer 2014 111 2220 2223 Lee HA Park S Kim Y Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells Oncol Rep 2013 30 1869 1877 Li Y Liu S Man Y Li N Zhou YU Effects of vitamins E and C combined with β-carotene on cognitive function in the elderly Exp Ther Med 2015 9 1489 1493 Lim JY Kim YS Kim KM Min SJ Kim Y Β-carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness Biochem Biophys Res Commun 2014 450 1475 1480 Lim JY Kim YS Kim Y β-carotene regulates the murine liver microenvironment of a metastatic neuroblastoma J Cancer Prev 2013 18 337 345 Lin C Yon JM Jung AY Lee JG Jung KY Lee BJ Antiteratogenic effects of β-carotene in cultured mouse embryos exposed to nicotine Evid Based Complement Alternat Med 2013 2013 575287 Nishida K Sugimoto M Ikeda S Kume S Effects of supplemental β-carotene on mucosal IgA induction in the jejunum and ileum of mice after weaning Br J Nutr 2014 111 247 253 Orazizadeh M Khorsandi L Absalan F Hashemitabar M Daneshi E Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice J Assist Reprod Genet 2014 31 561 568 Peng HC Chen YL Yang SY Ho PY Yang SS Hu JT The antiapoptotic effects of different doses of β-carotene in chronic ethanol-fed rats Hepatobiliary Surg Nutr 2013 2 132 141 Rotenstreich Y Belkin M Sadetzki S Chetrit A Ferman-Attar G Sher I Treatment with 9-cis β-carotene-rich powder in patients with retinitispigmentosa: a randomized crossover trial JAMA Ophthalmol 2013 131 985 992 Schnorr CE Morrone Mda S Simões-Pires A Bittencourt Lda S Zeidán-Chuliá F Moreira JC Supplementation of adult rats with moderate amounts of β-carotene modulates the redox status in plasma without exerting pro-oxidant effects in the brain: a safer alternative to food fortification with vitamin A? Nutrients 2014 6 5572 5582 Silva LS de Miranda AM de Brito Magalhães CL Dos Santos RC Pedrosa ML Silva ME Diet supplementation with beta-carotene improves the serum lipid profile in rats fed a cholesterol-enriched diet J Physiol Biochem 2013 69 811 820 Sluijs I Cadier E Beulens JW van der A DL Spijkerman AM vander Schouw YT Dietary intake of carotenoids and risk of type 2 diabetes Nutr Metab Cardiovasc Dis 2015 25 376 381 Sommer A Vyas KS A global clinical view on vitamin A and carotenoids Am J Clin Nutr 2012 96 1204S 1206S Tang G Techniques for measuring vitamin A activity from β-carotene Am J Clin Nutr 2012 96 1185S 1188S Vrolijk MF Opperhuizen A Jansen EH Godschalk RW Van Schooten FJ Bast A The shifting perception on antioxidants: The case of vitamin E and β-carotene Redox Biol 2015 4C 272 278 Wang HJ Liang R Fu LM Han RM Zhang JP Skibsted LH Nutritional aspects of β-carotene and resveratrol antioxidant synergism in giant unilamellar vesicles Food Funct 2014 5 1573 1578 Recent studies on carotene and its biological and pharmacological activities