Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis

Authors

  • Amir Asri Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Javid Sabour Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Amir Atashi Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Masoud Soleimani Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

DOI:

https://doi.org/10.17179/excli2014-585

Keywords:

CXCR7, CXCR4, CXCL12, HSCs homing

Abstract

Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a has been shown to bind CXCR7 in addition to CXCR4 and can also function as SDF1a/CXCR4 modulator. CXCR7 plays a role in HSCs homing via SDF1a gradient and is a mediator of CXCR4/SDF1a axis. This review describes the current concepts and questions concerning CXCR7/CXCR4/SDF1a axis as an important key in hematopoietic stem cells homing with particular emphasis on CXCR7 receptor. Homing of HSCs is an essential step for successful hematopoietic stem cell transplantation.

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Published

2016-02-15

How to Cite

Asri, A., Sabour, J., Atashi, A., & Soleimani, M. (2016). Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis. EXCLI Journal, 15, 134–143. https://doi.org/10.17179/excli2014-585

Issue

Vol. 15 (2016)

Section

Review articles

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