Connexins and pannexins in liver damage

Authors

  • Sara Crespo Yanguas Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
  • Joost Willebrords Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
  • Michaël Maes Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
  • Tereza Cristina da Silva Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo SP CEP 05508-900, Brazil
  • Isabel Veloso Alves Pereira Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo SP CEP 05508-900, Brazil
  • Bruno Cogliati Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo SP CEP 05508-900, Brazil
  • Maria Lucia Zaidan Dagli Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo SP CEP 05508-900, Brazil
  • Mathieu Vinken Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium

DOI:

https://doi.org/10.17179/excli2016-119

Keywords:

connexin, pannexin, acute liver injury, steatosis, hepatitis, cholestasis, fibrosis, liver cancer

Abstract

Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.

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Published

2016-02-25

How to Cite

Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Veloso Alves Pereira, I., Cogliati, B., … Vinken, M. (2016). Connexins and pannexins in liver damage. EXCLI Journal, 15, 177–186. https://doi.org/10.17179/excli2016-119

Issue

Vol. 15 (2016)

Section

Review articles

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