Antioxidant, anti-inflammatory and anticancer activities of the medicinal halophyte Reaumuria vermiculata

Authors

  • Manel Karker Laboratory of Aromatic and Medicinal Plants, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia
  • Hanen Falleh Laboratory of Aromatic and Medicinal Plants, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia
  • Kamel Msaada Laboratory of Aromatic and Medicinal Plants, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia
  • Abderrazak Smaoui Extêmophiles Plants Laboratory, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia
  • Chedly Abdelly Extêmophiles Plants Laboratory, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia
  • Jean Legault LASEVE Laboratory, Québec University in Chicoutimi, 555 University Boulevard, G7H 2B1Chicoutimi, Québec, Canada
  • Riadh Ksouri Laboratory of Aromatic and Medicinal Plants, Biotechnology center of Borj-Cédria, BP 901, 2050 Hammam-lif, Tunisia

DOI:

https://doi.org/10.17179/excli2016-187

Keywords:

Reaumuria vermiculata, phenolic compounds, antioxidant activity, anti-inflammatory, anticancer, RP-HPLC

Abstract

Reaumuria vermiculata is a xero-halophytic specie widely distributed in the south of Tunisia. In the current study, antioxidant, anti-inflammatory and anticancer activities of Reaumuria vermiculata shoot extracts as well as its phenolic compounds were investigated in different solvent extracts (hexane, dichloromethane, methanol and water). Results showed a strong antioxidant activity, using the ORAC method and a cell based-assay, in methanol extract as well as an important phenolic composition (117.12 mg GAE/g). Hexane and dichloromethane proved an interesting anticancer activity against A-549 lung carcinoma cells, with IC50 values of 17 and 23 µg/ml, respectively. Besides, dichloromethane extract displayed the utmost anti-inflammatory activity, inhibiting NO release over 100 % at 80 µg/ml in LPS-stimulated RAW 264.7. Taken together, these finding suggest that R. vermiculata exhibited an interesting biological activities which may be related to the phenolic composition of this plant. Moreover, the identification of phenolic compounds in R. vermiculata dichloromethane extract using RP-HPLC revealed that myricetin was the major molecule. These results allow us to propose R. vermiculata as a valuable source for bioactive and natural compounds exhibiting interesting biological capacities.

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Published

2016-04-25

How to Cite

Karker, M., Falleh, H., Msaada, K., Smaoui, A., Abdelly, C., Legault, J., & Ksouri, R. (2016). Antioxidant, anti-inflammatory and anticancer activities of the medicinal halophyte Reaumuria vermiculata. EXCLI Journal, 15, 297–307. https://doi.org/10.17179/excli2016-187

Issue

Vol. 15 (2016)

Section

Original articles

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