Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

Authors

  • Dalia Azmy Elberry Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt
  • Shaimaa Nasr Amin Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt
  • Reham Shehab El Nemr Esmail Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt
  • Laila Ahmed Rashed Department of Biochemistry, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt
  • Maha Mohamed Gamal Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt

DOI:

https://doi.org/10.17179/excli2016-645

Keywords:

liver, hepatic encephalopathy, stem cells, hippocampus, basal ganglia

Abstract

Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versus in vitro partially differentiated mesenchymal stem cells on liver cirrhosis and hepatic encephalopathy. 50 adult male albino rats constituted the animal model and were divided into the following groups: control, thioacetamide, undifferentiated mesenchymal stem cells and hepatocyte growth factor-differentiated mesenchymal stem cells groups. Cognitive assessment was achieved by open field test and Y-maze task. We measured serum alanine aminotransferase, albumin and transforming growth factor-beta1, gene expression of α-smooth muscle actin, matrix metalloprotein-2, its tissue inhibitor and apoptotic markers: Bax and Bcl2, brain glial fibrillary acidic protein, synaptophysin, and dopaminergic receptors.

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Published

2016-11-07

How to Cite

Elberry, D. A., Amin, S. N., Esmail, R. S. E. N., Rashed, L. A., & Gamal, M. M. (2016). Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis. EXCLI Journal, 15, 652–670. https://doi.org/10.17179/excli2016-645

Issue

Vol. 15 (2016)

Section

Original articles

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