Feeding to satiation induces mild oxidative/carbonyl stress in the brain of young mice

Authors

  • Oksana V. Kuzniak Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0002-2392-9619
  • Oksana M. Sorochynska Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0001-5773-760X
  • Maria M. Bayliak Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0001-6268-8910
  • Andrii Ya. Klonovskyi Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0001-5719-6751
  • Yulia V. Vasylyk Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0003-0614-2870
  • Halyna M. Semchyshyn Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine https://orcid.org/0000-0002-5967-2165
  • Kenneth B. Storey Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada https://orcid.org/0000-0002-7363-1853
  • Olga Garaschuk Department of Neurophysiology, Institute of Physiology, University of Tübingen, 72074 Tübingen, Germany https://orcid.org/0000-0001-7400-5654
  • Volodymyr I. Lushchak Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine. E-mail: lushchak@pnu.edu.ua https://orcid.org/0000-0001-5602-3330

DOI:

https://doi.org/10.17179/excli2021-4347

Keywords:

defensive enzymes, carbonyl proteins, α-dicarbonyl compounds, every-other-day fasting, lipid peroxides

Abstract

Intermittent fasting as a dietary intervention can prevent overweight and obesity in adult organisms. Nevertheless, information regarding consequences of intermittent fasting for redox status and reactive metabolite-mediated processes that are crucial for the normal functioning of organisms is limited. Since the information on effects of intermittent fasting on parameters of oxidative/carbonyl stress in the brains of young mice was absent, the present study addressed these questions using an every-other-day fasting (EODF) protocol. The levels of carbonyl proteins were ~28 %, 22 % and 18 % lower in the cerebral cortex of EODF males and females and middle parts of the brain of EODF males, respectively, as compared to their ad libitum fed counterparts. Lipid peroxides and α-dicarbonyl compounds were lower only in the cortex and medulla part of EODF male brain. The EODF regimen resulted in higher total non-specific antioxidant capacity in different parts of male brain and a tendency to be higher this parameter in females. At the same time, EODF regimen had no effect on the activities of the defensive antioxidant enzymes, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, glyoxylase 1 and glucose-6-phosphate dehydrogenase in the cortex of both sexes, but even decreased activities of these enzymes in medulla and middle part of the brain. In general, the results suggest that in the brain of young mice ad libitum feeding induces mild oxidative/carbonyl stress which may be partially alleviated by the EODF regimen. The effect of EODF regimen is more pronounced in the medulla part than in the cortex.

Author Biography

Olga Garaschuk, Department of Neurophysiology, Institute of Physiology, University of Tübingen, 72074 Tübingen, Germany

hatte die ORCID von Kenneth Storey im Feld, gelöscht, 10.12.2021, Lindemann

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Published

2022-01-05

How to Cite

Kuzniak, O. V., Sorochynska, O. M. ., Bayliak, M. M., Klonovskyi, A. Y., Vasylyk, Y. V., Semchyshyn, H. M., … Lushchak, V. I. (2022). Feeding to satiation induces mild oxidative/carbonyl stress in the brain of young mice. EXCLI Journal, 21, 77–92. https://doi.org/10.17179/excli2021-4347

Issue

Vol. 21 (2022)

Section

Original articles

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Copyright (c) 2022 Oksana V. Kuzniak, Oksana M. Sorochynska, Maria M. Bayliak, Andrii Ya. Klonovskyi, Yulia V. Vasylyk, Halyna M. Semchyshyn, Kenneth B. Storey, Olga Garaschuk, Volodymyr I. Lushchak

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