Molecular mechanisms linking stress and insulin resistance


  • Habib Yaribeygi Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran. E-mail:
  • Mina Maleki Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Alexandra E. Butler Research Department, Royal College of Surgeons in Ireland, Bahrain, PO Box 15503, Adliya, Bahrain
  • Tannaz Jamialahmadi Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Amirhossein Sahebkar Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail:



Diabetes mellitus, insulin resistance, stress, immune system, insulin signal transduction


To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.



How to Cite

Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2022). Molecular mechanisms linking stress and insulin resistance. EXCLI Journal, 21, 317–334.



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