Enhancing the efficacy of albendazole for liver cancer treatment using mesoporous silica nanoparticles

an in vitro study

Authors

  • Mohsen Ghaferi Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran https://orcid.org/0000-0002-6784-8300
  • Warda Zahra Nishtar Medical University and Hospital, Multan 60000, Pakistan http://orcid.org/0000-0003-2020-1275
  • Azim Akbarzadeh Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran http://orcid.org/0000-0002-4803-1506
  • Hasan Ebrahimi Shahmabadi Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Postal code: 7717933777, Tel: +983431315043, E-mail: ebrahimi@rums.ac.ir https://orcid.org/0000-0001-5222-3829
  • Seyed Ebrahim Alavi Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Postal code: 7717933777, Tel: +983431315043, E-mail: s.ebrahimalavi@gmail.com https://orcid.org/0000-0003-4009-4921

DOI:

https://doi.org/10.17179/excli2021-4491

Keywords:

albendazole, cancer, drug delivery, MCM-41, mesoporous silica nanoparticles

Abstract

The present study aimed to synthesize albendazole (ABZ)-loaded Mobil Composition of Matter No. 41 (MCM-41 NPs) to increase the efficacy of the drug against liver cancer. ABZ was loaded into MCM-41 NPs, and after in vitro characterization, such as size, size distribution, zeta potential, morphology, chemical composition, thermal profile, drug release, surface and pore volume, and pore size, their biological effects were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) cell migration assays. The results demonstrated that monodispersed and spherical NPs with a size of 220 ± 11.5 and 293 ± 8.7 nm, for MCM-41 NPs and ABZ-loaded MCM-41 NPs, respectively, and drug loading efficiency of 30 % were synthesized. ABZ was loaded physically into MCM-41 NPs, leading to a decrease in surface volume, pore size, and pore volume. Also, MCM-41 NPs could increase the cytotoxicity effects of ABZ by 2.9-fold (IC50 = 23 and 7.9 µM for ABZ and ABZ-loaded MCM-41 NPs, respectively). In addition, both ABZ and ABZ-loaded MCM-41 NPs could restrain the cell migration by 12 %. Overall, the results of the present study suggest evaluating the potency of MCM-41 NPs, as a potent nanoplatform, for ABZ delivery in vivo environment.

Author Biography

Azim Akbarzadeh, Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran

email-Adresse stimmt nicht! reklamiert, 16.11.2021 (Susanne); obige email am 17.11.2021 erhalten

Additional Files

Published

2022-01-11

How to Cite

Ghaferi, M., Zahra, W., Akbarzadeh, A., Ebrahimi Shahmabadi, H., & Alavi, S. E. (2022). Enhancing the efficacy of albendazole for liver cancer treatment using mesoporous silica nanoparticles: an in vitro study. EXCLI Journal, 21, 236–249. https://doi.org/10.17179/excli2021-4491

Issue

Section

Original articles