LOX-1: Implications in atherosclerosis and myocardial ischemia

Authors

  • Tanya Sharma Division of Cardiology, Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA https://orcid.org/0000-0002-2663-8243
  • Francesco Romeo Department of Cardiology, International University Unicamillus, Rome, Italy https://orcid.org/0000-0002-6176-1159
  • Jawahar L. Mehta Division of Cardiology, Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, 4300 W Markham St., Little Rock, AR 72205-4024, USA Tel.: 001-501-296-1426; E-mail: MehtaJL@uams.edu https://orcid.org/0000-0003-0384-2097

DOI:

https://doi.org/10.17179/excli2021-4532

Keywords:

atherosclerosis, myocardial ischemia, oxidized-LDL,, LOX-1

Abstract

Understanding the pathophysiology of atherosclerosis is fundamental to the practice of cardiovascular medicine. Atherosclerosis is a multi-step cascade of accumulation of lipids and downstream changes that lead to a fibro-fatty plaque formation in the arterial intima. Multiple biochemical stimuli, cellular receptors and intra-cellular signals are implicated in this complex mechanism. Lectin-type oxidized LDL receptor-1 or LOX-1 is a type II membrane glycoprotein receptor which has emerged as an important effector of atherosclerosis. Hence, LOX-1 modification and its clinical consequences are of much interest in recent times.

Downloads

Published

2022-01-13

How to Cite

Sharma, T., Romeo, F., & Mehta, J. L. (2022). LOX-1: Implications in atherosclerosis and myocardial ischemia. EXCLI Journal, 21, 273–278. https://doi.org/10.17179/excli2021-4532

Issue

Vol. 21 (2022)

Section

Review articles

License

Copyright (c) 2022 Tanya Sharma, Francesco Romeo, Jawahar L. Mehta

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).