Oxidative stress and visual system
a review
DOI:
https://doi.org/10.17179/excli2022-4663Keywords:
α-lipoic acid (ALA), antioxidants, retina and optic nerve aging, superoxide dismutase (SOD)Abstract
Different types of tissues respond differently to the action of oxidative stress. The visual system is very sensitive to oxidative action due to continuous exposure to light. In consideration of the growing interest of scientific studies towards various compounds endowed with antioxidant and anti-inflammatory properties, we performed a review of the literature focusing on the use of some antioxidant molecules for the treatment of conditions affecting the visual system. In this study, we focused on the ability of two antioxidant agents, the small molecule α-lipoic acid (ALA) and the enzyme superoxide dismutase (SOD), to influence the neurodegenerative physiological processes related to aging and oxidative stress affecting the ocular segment. The literature data report that ALA and SOD can protect against neurodegenerative effects both the optic nerve and retina and, if administered together, they are able to lower the levels of oxidative stress, thus preventing neurodegeneration and reducing the apoptotic process.
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Copyright (c) 2022 Samanta Taurone, Massimo Ralli, Marco Artico, Valentina Noemi Madia, Susanna Scarpa, Stefania Annarita Nottola, Antonio Maconi, Marta Betti, Pietro Familiari, Marcella Nebbioso, Roberta Costi, Alessandra Micera
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