The effect of exercise interventions on Irisin level

a systematic review and meta-analysis of randomized controlled trials


  • Gholam Rasul Mohammad Rahimi Department of Sports Sciences, Vahdat Institute of Higher Education, Torbat-e-Jam, Iran
  • Keyvan Hejazi Department of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran. Tel: +98 (51) 344012620, E-mail:
  • Martin Hofmeister Department Food and Nutrition, Consumer Center of the German Federal State of Bavaria, Munich, Germany



Irisin, exercise inteervention, FNDC5, PGC-1α, meta-analysis


Irisin is a hormone that is offered to be a hopeful remedial target in obesity and type 2 diabetes. It has received striking attention recently, whereas, the interactions between exercise training and irisin are still unclear. Therefore, this systematic review and meta-analysis investigated the impacts of exercise interventions on circulating irisin in adults. A systematic search was conducted in PubMed, CINAHL, MEDLINE, Cochrane, Google Scholar, and Scopus up to July 15, 2021. Twenty-four studies, which assessed a total of 921 participants were included and analyzed using a random-effects model to estimate weighted mean differences (MD) with 95 % confidence intervals (CI). Overall, data revealed that exercise training significantly increased circulating irisin (MD: 0.01, 95 % CI: 0.00, 0.01, p = 0.005), and declined insulin (MD: -2.09, 95 % CI: -2.81, -1.37, p < 0.00001), glucose (MD: -12.89, 95 % CI: -16.52, -9.26, p < 0.00001), and insulin resistance (MD: -0.89, 95 % CI: -1.15, -0.62, p < 0.00001). Subgroup analysis revealed that irisin raised significantly when resistance training (p = 0.04) and combined training (p = 0.002) were applied, and for the type 2 diabetes and prediabetes (p = 0.002 for both) groups. Moreover, subgroup analysis by the type of intervention demonstrated that insulin reduced when aerobic training (p < 0.00001) and combined training (p = 0.0003) were employed, but glucose and HOMA-IR reduced after all three types of exercise training. These findings demonstrate that exercise interventions may produce ameliorations in circulating irisin. Further long-term studies are required to confirm these findings.



How to Cite

Mohammad Rahimi, G. R., Hejazi, K., & Hofmeister, M. (2022). The effect of exercise interventions on Irisin level: a systematic review and meta-analysis of randomized controlled trials. EXCLI Journal, 21, 524–539.



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