Effects of curcumin on low-density lipoprotein oxidation

From experimental studies to clinical practice

Authors

  • Fatemeh Baratzadeh School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran https://orcid.org/0000-0003-1499-2891
  • Alexandra E. Butler Research Department, Royal College of Surgeons in Ireland, PO Box 15503, Adliya, Bahrain https://orcid.org/0000-0002-5762-3917
  • Prashant Kesharwani Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India https://orcid.org/0000-0002-0890-769X
  • Seyed Adel Moallem Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-4507-2932
  • Amirhossein Sahebkar Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran. E-mail: sahebkara@mums.ac.ir; amir_saheb2000@yahoo.com https://orcid.org/0000-0002-8656-1444

DOI:

https://doi.org/10.17179/excli2022-4878

Keywords:

oxidized low density lipoprotein, ox-LDL, anti-ox-LDL, Curcumin, Turmeric, Curcuma longa

Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

Published

2022-06-22

How to Cite

Baratzadeh, F., Butler, A. E., Kesharwani, P., Moallem, S. A., & Sahebkar, A. (2022). Effects of curcumin on low-density lipoprotein oxidation: From experimental studies to clinical practice. EXCLI Journal, 21, 840–851. https://doi.org/10.17179/excli2022-4878

Issue

Section

Review articles

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