Effects of curcumin on low-density lipoprotein oxidation
From experimental studies to clinical practice
Keywords:oxidized low density lipoprotein, ox-LDL, anti-ox-LDL, Curcumin, Turmeric, Curcuma longa
Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.
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Copyright (c) 2022 Fatemeh Baratzadeh, Alexandra E. Butler, Prashant Kesharwani, Seyed Adel Moallem, Amirhossein Sahebkar
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