Effects of curcumin on low-density lipoprotein oxidation

From experimental studies to clinical practice

Authors

  • Fatemeh Baratzadeh School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran https://orcid.org/0000-0003-1499-2891
  • Alexandra E. Butler Research Department, Royal College of Surgeons in Ireland, PO Box 15503, Adliya, Bahrain https://orcid.org/0000-0002-5762-3917
  • Prashant Kesharwani Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India https://orcid.org/0000-0002-0890-769X
  • Seyed Adel Moallem Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-4507-2932
  • Amirhossein Sahebkar Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran. E-mail: sahebkara@mums.ac.ir; amir_saheb2000@yahoo.com https://orcid.org/0000-0002-8656-1444

DOI:

https://doi.org/10.17179/excli2022-4878

Keywords:

oxidized low density lipoprotein, ox-LDL, anti-ox-LDL, Curcumin, Turmeric, Curcuma longa

Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

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Published

2022-06-22

How to Cite

Baratzadeh, F., Butler, A. E., Kesharwani, P., Moallem, S. A., & Sahebkar, A. (2022). Effects of curcumin on low-density lipoprotein oxidation: From experimental studies to clinical practice. EXCLI Journal, 21, 840–851. https://doi.org/10.17179/excli2022-4878

Issue

Vol. 21 (2022)

Section

Review articles

Categories

License

Copyright (c) 2022 Fatemeh Baratzadeh, Alexandra E. Butler, Prashant Kesharwani, Seyed Adel Moallem, Amirhossein Sahebkar

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