Is autophagy associated with diabetes mellitus and its complications? A review

Authors

  • Debalina Bhattacharya Department of Biochemistry, University of Calcutta, Kolkata-700019; Department of Life Science and Biotechnology, Jadavpur University, Kolkata-700032
  • Mainak Mukhopadhyay Department of Biotechnology, JIS University, Agarpara, Kolkata-700109
  • Maitree Bhattacharyya Department of Biochemistry, University of Calcutta, Kolkata-700019
  • Parimal Karmakar Department of Life Science and Biotechnology, Jadavpur University, Kolkata-700032

DOI:

https://doi.org/10.17179/excli2018-1353

Keywords:

type 2 diabetes mellitus, T2DM, autophagy, retinopathy, cardiomyopathy, nephropathy

Abstract

Diabetes mellitus (DM) is an endocrine disorder. In coming decades it will be one of the leading causes of death globally. The key factors in the pathogenesis of diabetes are cellular injuries and disorders of energy metabolism leading to severe diabetic complications. Recent studies have confirmed that autophagy plays a pivotal role in diabetes and its complications. It has been observed that autophagy regulates the normal function of pancreatic β cells and insulin-target tissues, such as skeletal muscle, liver, and adipose tissue. This review will summarize the regulation of autophagy in diabetes and its complications, and explore how this process would emerge as a potential therapeutic target for diabetes treatment.

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Published

2018-07-24

How to Cite

Bhattacharya, D., Mukhopadhyay, M., Bhattacharyya, M., & Karmakar, P. (2018). Is autophagy associated with diabetes mellitus and its complications? A review. EXCLI Journal, 17, 709–720. https://doi.org/10.17179/excli2018-1353

Issue

Vol. 17 (2018)

Section

Review articles

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