Nanocarriers for delivery of siRNA as gene silencing mediator

Authors

  • Aideé Morales-Becerril Laboratorio de Toxicología y Farmacia, Facultad de Química, Universidad Autónoma del Estado de México, Toluca, Estado de México 50120, México https://orcid.org/0000-0003-0755-7680
  • Liliana Aranda-Lara Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México 50180, México https://orcid.org/0000-0003-4066-2327
  • Keila Isaac-Olivé Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México 50180, México https://orcid.org/0000-0003-4388-3811
  • Blanca E. Ocampo-García Laboratorio Nacional de Investigación y Desarrollo de Radiofarmacos-CONACyT, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, México https://orcid.org/0000-0002-5831-8412
  • Enrique Morales-Avila Facultad de Química, Universidad Autónoma del Estado de México, Paseo Tollocan esq Paseo Colón S/N., Toluca, Estado de México. C.P. 50120, México. Tel. + (52) (722) 2 17 41 20, Fax. + (52) (722) 2 17 38 90, E-mail: enrimorafm@yahoo.com.mx or emoralesav@uaemex.mx https://orcid.org/0000-0001-8471-6791

DOI:

https://doi.org/10.17179/excli2022-4975

Keywords:

siRNA, nanocarrier, drug delivery systems, nanomedicine

Abstract

The term nanocarrier refers to sub-micrometric particles of less than 100 nm, designed to transport, distribute, and release nanotechnology-based drug delivery systems. siRNA therapy is a novel strategy that has great utility for a variety of treatments, however naked siRNA delivery has not been an effective strategy, resulting in the necessary use of nanocarriers for delivery. This review aims to highlight the versatility of carriers based on smart drug delivery systems. The nanocarriers based on nanoparticles as siRNA DDS have provided a set of very attractive advantages related to improved physicochemical properties, such as high surface-to-volume ratio, versatility to package siRNA, provide a dual function to both protect extracellular barriers that lead to elimination and overcome intracellular barriers limiting cytosolic delivery, and possible chemical modifications on the nanoparticle surface to improve stability and targeting. Lipid and polymeric nanocarriers have proven to be stable, biocompatible, and effective in vitro, further exploration of the development of new nanocarriers is needed to obtain safe and biocompatible tools for effective therapy.

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Published

2022-08-01

How to Cite

Morales-Becerril, A., Aranda-Lara, L., Isaac-Olivé, K., Ocampo-García, B. E., & Morales-Avila, E. (2022). Nanocarriers for delivery of siRNA as gene silencing mediator. EXCLI Journal, 21, 1028–1052. https://doi.org/10.17179/excli2022-4975

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Section

Review articles

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