Insights into the mechanisms of non-coding RNAs’ implication in the pathogenesis of Alzheimer’s disease

Authors

  • Majid Khodayi-Shahrak Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran https://orcid.org/0000-0002-5113-8582
  • Mohammad Khalaj-Kondori Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. E-mail: khalaj@tabrizu.ac.ir https://orcid.org/0000-0003-3990-5467
  • Mohammad Ali Hosseinpour Feizi Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran https://orcid.org/0000-0002-1508-5022
  • Mahnaz Talebi Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran https://orcid.org/0000-0002-7613-3913

DOI:

https://doi.org/10.17179/excli2022-5006

Keywords:

Alzheimer’s disease, Hypoxia, ERK, mitochondrial fission, BACE1, miRNAs, lncRNAs, marker

Abstract

Non-coding RNAs including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are implicated in the regulation of gene expression at transcriptional, posttranscriptional, and epigenetic levels. Several studies in cell lines, animal models, and humans, have revealed that non-coding RNAs play crucial roles in the pathogenesis of Alzheimer's disease (AD). Detailed knowledge on their mechanism of implication in the AD pathogenesis can help to develop novel therapeutic and disease management strategies. The two main pathological hallmarks of AD are amyloid plaques resulting from the β-amyloid accumulation, and neurofibrillary tangles (NFT) due to the phosphorylated tau accumulation. Several lncRNAs and miRNAs play crucial roles in both these hallmarks of the AD pathogenesis and other AD-related pathological procedures such as neuronal and synaptic plasticity, neuroinflammation, neuronal differentiation and neuronal apoptosis. In this review, we outlined the non-coding RNAs and further discussed how they are implicated in these AD-related pathological procedures.

Author Biography

Mohammad Ali Hosseinpour Feizi, Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

 

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Published

2022-06-30

How to Cite

Khodayi-Shahrak, M., Khalaj-Kondori, M., Hosseinpour Feizi, M. A., & Talebi, M. (2022). Insights into the mechanisms of non-coding RNAs’ implication in the pathogenesis of Alzheimer’s disease. EXCLI Journal, 21, 921–940. https://doi.org/10.17179/excli2022-5006

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Section

Review articles

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